Description: Many experiments have characterized the bidirectional relationship between sharp wave ripples (SPW-Rs) and activity in chosen brain areas. However, the topographic relationship between different segments of the hippocampus and brain-wide target areas has not been studied at high temporal and spatial resolution. This study analyzed two publicly available datasets with simultaneous high-density silicon probe recordings from across the mouse forebrain. The datasets were collected by investigators at the Allen Institute (Siegel et al.) and University College London (Steinmetz et al.). This study demonstrated that the activity patterns in extrahippocampal structures depend both on the intrahippocampal topographic origin and magnitude of hippocampal SPW-Rs.

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Restrictions: Free to All
Instructions: This study includes data from investigators at the Allen Institute (AI) and University College London (UCL), which are available at Allen SDK and figshare, respectively. All custom code used for this study is available on GitHub.; Access via Allen SDK
AI data

Access via figshare
UCL data

Access via GitHub
Custom code

Associated Publications

Nitzan N, Swanson R, Schmitz D, Buzsáki G. Brain-wide interactions during hippocampal sharp wave ripples. Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2200931119.

Siegle JH, Jia X, Durand S, Gale S, Bennett C, Graddis N, Heller G, Ramirez TK, Choi H, Luviano JA, Groblewski PA, Ahmed R, Arkhipov A, Bernard A, Billeh YN, Brown D, Buice MA, Cain N, Caldejon S, Casal L, Cho A, Chvilicek M, Cox TC, Dai K, Denman DJ, de Vries SEJ, Dietzman R, Esposito L, Farrell C, Feng D, Galbraith J, Garrett M, Gelfand EC, Hancock N, Harris JA, Howard R, Hu B, Hytnen R, Iyer R, Jessett E, Johnson K, Kato I, Kiggins J, Lambert S, Lecoq J, Ledochowitsch P, Lee JH, Leon A, Li Y, Liang E, Lo

Steinmetz NA, Zatka-Haas P, Carandini M, Harris KD. Distributed coding of choice, action and engagement across the mouse brain. Nature. 2019 Dec;576(7786):266-273.

Data Type

Electrophysiological

Behavioral

Equipment Used

Adafruit LG LP097QX1

Arduino Uno R3

ASUS ProArt PA248Q

Big Easy Driver

DMK 23U618

IDS UI-3280CP

Kent Scientific PhysioSuite

Kent Scientific SomnoSuite

Kubler 05.2400.1122.0360

Mightex SLS-0208-A

Multi-Probe Micromanipulator System

OD 2.0 Longpass Filter

Piezo Film Sensor Without Lead

PlatinumTL Telecentric Lens

Thorlabs ACL2520-DG6

Thorlabs DG20-600

Thorlabs FEL0750

Thorlabs M530L3

Thorlabs MNWHL4

Thorlabs MVL16M23

Thorlabs MVL7000

Thorlabs SM2F32-A

uMP-4 Micromanipulator

Zeiss Axioscan

Zyla 5.5 sCMOS

Software Used

Adobe Illustrator

Adobe Photoshop

DeepLabCut

FMAToolbox

Kilosort

Kilosort2

NRecon

Phy

PsychoPy

Python

μManager

Grant Support: U19 NS107616/NINDS NIH

U19 NS104590/NINDS NIH

R01 MH107396/NIMH NIH

EXC 2049/Deutsche Forschungsgemeinschaft

SFB 1315/Deutsche Forschungsgemeinschaft

Walter Benjamin Programme/Deutsche Forschungsgemeinschaft

NYU Data Catalog

Brain-Wide Interactions During Hippocampal Sharp Wave Ripples

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