This study profiled neurotrophin and neurotrophin receptor gene expression within microdissected CA1 neurons along with regional hippocampal dissections from participants in the Rush Religious Orders Study (RROS). The RROS participants included older religious clergy who have agreed to medical and psychological evaluation each year and brain donation after death. This study began in 1993 and has enrolled more than 1,100 participants across the United States. The study has 22 years of clinical data on more than 1,100 people and brain tissue from over 350 people. Gene expression profiles of CA1 pyramidal neurons and the surrounding hippocampal formation were examined using custom-designed microarray and qPCR analysis applied to postmortem human brain tissue. This dataset contains microarray data, which indicate a significant downregulation of several neurotrophin genes in CA1 pyramidal neurons.