This dataset is a product of an investigation of microbe-metabolite relationships in the gut as a means to understand and potentially reduce colorectal cancer (CRC) risk. Microbiota and metabolomics profiling was performed on lyophilized feces from 42 colorectal cancer cases and 89 matched controls. Multivariable logistic regression was used to identify statistically independent associations with CRC....

This dataset includes 330 Emirati adults participating in the UAE Healthy Future Study-Pilot (UAEHFS-pilot) who provided mouthwash samples. There were 225 non-smokers and 105 smokers who used cigarettes, dokha, shisha, or a combination of tobacco products. 101 of the 105 smokers were male. Tobacco use and frequency were assessed with a structured questionnaire and urine cotinine lab results. Gene...

This study characterized gut microbiome in pre-treatment stool using 16S rRNA gene and shotgun metagenome sequencing in melanoma patients undergoing immunotherapy. Transcriptional expression of metagenomic pathways was confirmed with metatranscriptome sequencing. Metatranscriptomics is important for determining expression of metagenomic functions in the microbial community. They also examined associations...

The data from this study shows that early-life antibiotic use may affect the progression of subsequent disease conditions by changing host microbiota and immunologic development. For this study, they used a murine model of dextran sodium sulfate (DSS)-induced colitis and evaluated the effect on disease outcomes of early-life pulsed antibiotic treatment (PAT). The dataset includes 16S sequencing data....

Generation R is an ongoing prospective cohort study of child development from the prenatal period through young adulthood in a multi-ethnic population recruited from the Rotterdam, Netherlands metropolitan area. The study enrolled 9,778 mothers with a delivery date between April 2002 and January 2006; they had 9,749 live births. The primary objective of the study is to identify early environmental...

Patients with Alzheimer’s disease (AD) have altered intestinal microbiota. Studies have shown that reduced intestinal microbiota in AD animal models decreases amyloid-beta (Aβ) plaque deposition. This age-related changes in the microbiota contribute to immunologic and physiologic decline. Previous study indicated that calorie restriction (CR) reduced brain Aβ deposition in Tg2576 mouse model of AD....

Between August 2017 and April 2019, 303 women in their first or second gestational trimester were enrolled in an interventional randomized controlled trial to investigate the outcomes associated with dietary plans with different proportions of total carbohydrates. Eligible women were aged 18 to 45 years old who did not have a high risk pregnancy, chronic renal disease, cancer, congestive heart failure,...

To investigate the relationship between gut microbiome dysbiosis and translocation of bacteria into the blood during SARS-CoV-2 infection in humans, researchers obtained blood culture and stool samples from positive COVID-19 patients who were seen at NYU Langone Health and Yale New Haven Hospital. 67 stool samples were obtained from 60 patients at NYU Langone Health and 63 samples were obtained from...

Early-life antibiotic exposures during postnatal development have lasting effects on microbiota composition. Previous studies in humans and mice have found altered microbial composition to be associated with enhanced disease susceptibility and modified immune status. They investigated impact of timing of antibiotic exposure by treating 5 to 9 days C57BL/6J mice with two of the most commonly prescribed...

This study identified the gut microbiome during an acute enteric infection in patients with and without inflammatory bowel disease (IBD). A cross-sectional study was performed on 260 patients who underwent stool testing and tested positive for Clostridioides difficile, Escherichia coli, or norovirus, or negative for all pathogens, and 25 healthy controls. They collected the following data from the...