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NYU Dataset
Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability
- Authors
- Vladislav O. SviderskiyLili BlumenbergElizabeth GorodetskyTriantafyllia Karakousi13 more author(s)...
- Description
This study showed that basal-like breast cancer (BLBC) is sensitive to suppression of iron-sulfur cluster (ISC) biosynthesis and identified DNA polymerase epsilon (POLE) as an ISC-containing protein that underlies this phenotype. This dataset includes RNA sequencing data and data underlying figures. The publication also contains supplementary data, which includes data for short hairpin RNA (shRNA)...
- Subject
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CancerGenomics
- Access Rights
- Free to All
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NYU Dataset
Comprehensive Analysis of Regenerative and Transformed Liver
- Authors
- Daniel J. McLaughlinHannan MirMinwoo NamRichard Possemato
- Description
This study performed a differential transcriptomic and metabolomic analysis of benign proliferative and transformed liver. They used partial hepatectomy-induced liver regeneration and diethylnitrosamine induced carcinogenesis to identify and analyze alterations specific to multiple regenerative and transformed tissue states. This dataset contains supplementary data tied to the publication. Supplementary...
- Subject
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Genomics
- Access Rights
- Free to All
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NYU Dataset
Identification of PIM1 Substrates Reveals a Role for NDRG1 Phosphorylation in Prostate Cancer
- Authors
- Russell J. LedetSophie E. RuffYu WangShruti Nayak4 more author(s)...
- Description
This study performed a chemical genetic screen to identify PIM1 substrates in prostate cancer cells. They identified 25 previously unknown PIM1 substrates and their phosphorylation sites. Among the identified PIM1 substrates, N-Myc Downstream-Regulated Gene 1 (NDRG1) was shown to be as an inhibitor of metastasis. The study demonstrated that PIM1 phosphorylation of NDRG1 reduced its stability, nuclear...
- Subject
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CancerProteomics
- Access Rights
- Free to All
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NYU Dataset
Targeting of Intracellular Oncoproteins with Peptide-Centric Chimeric Antigen Receptors
- Authors
- Mark YarmarkovichQuinlen F. MarshallJohn M. WarringtonRasika Premaratne24 more author(s)...
- Description
This study demonstrated that the neuroblastoma immunopeptidome is enriched with peptides derived from proteins essential for tumorigenesis. They targeted the unmutated peptide QYNPIRTTF discovered on HLA-A*24:02, which is derived from the neuroblastoma-dependency gene and master transcriptional regulator PHOX2B. To target QYNPIRTTF, they developed peptide-centric chimeric antigen receptors (PC-CARs)...
- Subject
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CancerProteomics
- Access Rights
- Free to All