NYU Data Catalog

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Results Found: 4
  • NYU Dataset

    Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability

    Authors
    Vladislav O. Sviderskiy
    Lili Blumenberg
    Elizabeth Gorodetsky
    Triantafyllia Karakousi
    13 more author(s)...
    Description

    This study showed that basal-like breast cancer (BLBC) is sensitive to suppression of iron-sulfur cluster (ISC) biosynthesis and identified DNA polymerase epsilon (POLE) as an ISC-containing protein that underlies this phenotype. This dataset includes RNA sequencing data and data underlying figures. The publication also contains supplementary data, which includes data for short hairpin RNA (shRNA)...

    Subject
    Cancer
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    Comprehensive Analysis of Regenerative and Transformed Liver

    Authors
    Daniel J. McLaughlin
    Hannan Mir
    Minwoo Nam
    Richard Possemato
    Description

    This study performed a differential transcriptomic and metabolomic analysis of benign proliferative and transformed liver. They used partial hepatectomy-induced liver regeneration and diethylnitrosamine (DEN) induced carcinogenesis to identify and analyze alterations specific to multiple regenerative and transformed tissue states. This dataset contains supplementary data tied to the publication. The...

    Subject
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    Identification of PIM1 Substrates Reveals a Role for NDRG1 Phosphorylation in Prostate Cancer

    Authors
    Russell J. Ledet
    Sophie E. Ruff
    Yu Wang
    Shruti Nayak
    4 more author(s)...
    Description

    This study performed a chemical genetic screen to identify PIM1 substrates in prostate cancer cells. They identified 25 previously unknown PIM1 substrates and their phosphorylation sites. Among the identified PIM1 substrates, N-Myc Downstream-Regulated Gene 1 (NDRG1) was shown to be as an inhibitor of metastasis. The study demonstrated that PIM1 phosphorylation of NDRG1 reduced its stability, nuclear...

    Subject
    Cancer
    Proteomics
    Access Rights
    Free to All
  • NYU Dataset

    Targeting of Intracellular Oncoproteins with Peptide-Centric Chimeric Antigen Receptors

    Authors
    Mark Yarmarkovich
    Quinlen F. Marshall
    John M. Warrington
    Rasika Premaratne
    24 more author(s)...
    Description

    This study demonstrated that the neuroblastoma immunopeptidome is enriched with peptides derived from proteins essential for tumorigenesis. They targeted the unmutated peptide QYNPIRTTF discovered on HLA-A*24:02, which is derived from the neuroblastoma-dependency gene and master transcriptional regulator PHOX2B. To target QYNPIRTTF, they developed peptide-centric chimeric antigen receptors (PC-CARs)...

    Subject
    Cancer
    Proteomics
    Access Rights
    Free to All