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NYU Dataset
Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition
- Authors
- Bryan NgoEugenie KimVictoria Osorio-VasquezSophia Doll36 more author(s)...
- Description
Brain metastasis is the most common intracranial malignancy in adults, which is often fatal. Studies have shown that brain metastases depend on cooperative cellular interactions between tumor cells and specialized cells within the central nervous system (CNS). Metabolic constraints imposed by the serine and glycine limited brain environment restrict metastatic tumor growth. This study showed that 3-phosphoglycerate...
- Subject
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NeuroscienceProteomics
- Access Rights
- Application RequiredAuthor Approval Required
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NYU Dataset
Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl tRNAs Requires SHMT2
- Authors
- Denise R. MintonMinwoo NamDaniel J. McLaughlinJong Shin7 more author(s)...
- Description
Eukaryotic cells upregulate oxidative metabolism to maintain homeostasis upon glucose restriction. This study used CRISPR/Cas9-based screening to identify serine catabolic enzyme SHMT2. They found that the mitochondrial SHMT2 is required for robust mitochondrial oxygen consumption and low glucose proliferation. This dataset contains immunoblot images, as well as supplementary data tied to the publication....
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Genomics
- Access Rights
- Free to All
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NYU Dataset
Comprehensive Analysis of Regenerative and Transformed Liver
- Authors
- Daniel J. McLaughlinHannan MirMinwoo NamRichard Possemato
- Description
This study performed a differential transcriptomic and metabolomic analysis of benign proliferative and transformed liver. They used partial hepatectomy-induced liver regeneration and diethylnitrosamine (DEN) induced carcinogenesis to identify and analyze alterations specific to multiple regenerative and transformed tissue states. This dataset contains supplementary data tied to the publication. The...
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Genomics
- Access Rights
- Free to All
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NYU Dataset
Identification of PIM1 Substrates Reveals a Role for NDRG1 Phosphorylation in Prostate Cancer
- Authors
- Russell J. LedetSophie E. RuffYu WangShruti Nayak4 more author(s)...
- Description
This study performed a chemical genetic screen to identify PIM1 substrates in prostate cancer cells. They identified 25 previously unknown PIM1 substrates and their phosphorylation sites. Among the identified PIM1 substrates, N-Myc Downstream-Regulated Gene 1 (NDRG1) was shown to be as an inhibitor of metastasis. The study demonstrated that PIM1 phosphorylation of NDRG1 reduced its stability, nuclear...
- Subject
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CancerProteomics
- Access Rights
- Free to All
