This dataset was compiled as part of the development of the Test of Everyday Cognitive Ability (TECA), a test of ten Timed Instrumental Activities of Daily Living (TIADLS) meant to measure a broad ranger or functioning. TECA’s performance was tested on 177 patients with MS and compared to healthy controls (49 subjects). Participants were recruited from the outpatient practices at Stony Brook Medicine’s...

This data was collected as part of a study of Pediatric-Onset Multiple Sclerosis (POMS), and to define the neuroanatomic underpinnings of deficits identified with cognitive screening batteries in POMS. Participants with POMS (n=15) were recruited through outpatients visits at the Lourie Center for Pediatric MS at Stony Brook University Health Center, and healthy controls (n=21) were recruited through...

This data was collected during clinical examinations at the NYU Comprehensive Epilepsy Center between the years of 2003 and 2008. Subjects included in this dataset have a confirmed epilepsy diagnosis from either routine electroencephalogram (EEG) or video-electroencephalogram (VEEG). The dataset does not include raw EEG data. There are 228 subjects in total. The following information was collected...

The NYU Alzheimer’s Disease Research Center (NYU ADRC) maintains a large database of standardized clinical and neuropathological research data collected at NYU Langone Health for local investigators, as well as those at affiliated or collaborating institutions. The NYU ADRC database includes a cumulative record of over 1,500 subjects enrolled since 1972. Data was collected every two years until 2005...

This dataset assesses the influence of timescale on the processing of visual stimuli. Following training sessions where they reached at least 76% accuracy, five human subjects (four male and one female) were presented with the following task: brief samples of a contrast pattern were presented on screen for 200 ms, followed by a pause before the subjects were prompted to match the samples to one of...

Using a Y-shaped maze, several experiments were developed to assess conditions of associative learning among fruit fly larvae. Prior to the start of the experiments, some fruit fly larvae were fed a diet of all-trans-retinal (ATR), which is a co-factor for csChrimson activation (eliciting escape behavior in flies which perceive red light). A subgroup of larvae who were fed ATR also received cycloheximide...

The Alzheimer’s Disease Neuroimaging Initiative (ADNI) began in 2004 as longitudinal multicenter study to identify clinical, imaging, genetic, and biochemical biomarkers for the detection and tracking of Alzheimer’s disease (AD). Participants are recruited from and followed at 59 research sites in the United States and Canada. ADNI1 enrolled 400 subjects who were diagnosed with mild cognitive impairment...

The National Alzheimer’s Coordinating Center (NACC) was created in 1999 to facilitate research with data collected from Alzheimer's Disease Research Centers (ADRCs) across the United States. NACC oversees data collection and sharing for a number of datasets. The Uniform Data Set (UDS) contains longitudinal and standardized data collected from ADRCs since 2005. ADRC enrollment protocols vary and...

This study examined how incorporation of synthetic hippocampal signals is constrained by pre-existing circuit dynamics. For this study, they optogenetically stimulated small groups of CA1 neurons as mice traversed a chosen segment of a linear track, which mimicked the emergence of place fields. Mice were trained to run laps on a linear track to retrieve water reward at each end. Before implantation,...

Learning and memory are presumed to be supported by mechanisms that involve cholinergic transmission and hippocampal theta. This study examined the effect of sustained cholinergic activation on memory performance. For this study, they used G protein-coupled receptor activation based acetylcholine sensor to monitor acetylcholine activity during memory performance in mice. The dataset contains behavioral,...