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Results Found: 5
  • NYU Dataset

    Immunotherapy Efficacy in Melanoma is Modulated by Gut Microbiota

    Authors
    Brandilyn A. Peters
    Melissa Wilson
    Una Moran
    Anna Pavlick
    5 more author(s)...
    Description

    This study characterized gut microbiome in pre-treatment stool using 16S rRNA gene and shotgun metagenome sequencing in melanoma patients undergoing immunotherapy. Transcriptional expression of metagenomic pathways was confirmed with metatranscriptome sequencing. Metatranscriptomics is important for determining expression of metagenomic functions in the microbial community. They also examined associations...

    Subject
    Genomics
    Access Rights
    Free to All

  • Bone marrow microenvironments that contribute to patient outcomes in newly diagnosed multiple myeloma

    Authors
    Samuel A. Danziger
    Mark McConnell
    Jake Gockley
    Mary H. Young
    29 more author(s)...
    Description

    This dataset contains data on the tumor microenvironment from the whole bone marrow of 436 patients who were diagnosed with multiple myeloma and enrolled in the interventional Total Therapy trial series conducted by the University of Arkansas for Medical Sciences. 266 male and 170 female patients were enrolled between February 25, 2004 and January 11, 2014 and completed 25 to 5,241 days of follow-up...

    Subject
    Cancer
    Chronic Disease
    Genomics
    Access Rights
    Free to All
    Local Expert
    Gareth J. Morgan
  • NYU Dataset

    Lymphatic Vessels Limits the Intratumoral T cell Repertoire in Melanoma

    Authors
    Maria M. Steele
    Ian D. Dryg
    Dhaarini Murugan
    Julia Femel
    6 more author(s)...
    Description

    CD8+ T cell accumulation in tumors is essential for effective immunotherapy. However, the mechanisms of lymphocyte transit are still unclear. This study examined lymphatic vessel-mediated effector CD8+ T cell exit limits the accumulation of a broad repertoire of functional CD8+ T cells that improve tumor control in combination with immune checkpoint blockade. They showed that tumor-associated lymphatic...

    Subject
    Cancer
    Genomics
    Access Rights
    Application Required
    Author Approval Required
  • NYU Dataset

    KEAP1 Mutation in Lung Adenocarcinoma Promotes Immune Evasion and Immunotherapy Resistance

    Authors
    Anastasia-Maria Zavitsanou
    Ray Pillai
    Yuan Hao
    Warren L. Wu
    23 more author(s)...
    Description

    Lung cancer is the leading cause of cancer related deaths worldwide and immunotherapy has become an important therapeutic intervention. Immunotherapy for lung cancer patients often fails with specific mutations like KEAP1. This study examined the impact of KEAP1 mutations on cancer growth and immune surveillance. They generated an orthotopic transplant model of KrasG12D/+; p53-/- lung cancer with cells...

    Subject
    Cancer
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    Targeting of Intracellular Oncoproteins with Peptide-Centric Chimeric Antigen Receptors

    Authors
    Mark Yarmarkovich
    Quinlen F. Marshall
    John M. Warrington
    Rasika Premaratne
    24 more author(s)...
    Description

    This study demonstrated that the neuroblastoma immunopeptidome is enriched with peptides derived from proteins essential for tumorigenesis. They targeted the unmutated peptide QYNPIRTTF discovered on HLA-A*24:02, which is derived from the neuroblastoma-dependency gene and master transcriptional regulator PHOX2B. To target QYNPIRTTF, they developed peptide-centric chimeric antigen receptors (PC-CARs)...

    Subject
    Cancer
    Proteomics
    Access Rights
    Free to All