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NYU Dataset
PIM1 Phosphorylation Regulates Gene Transcription in Prostate Cancer
- Authors
- Sophie E. RuffNikita VasilyevEvgeny NudlerSusan K. Logan1 more author(s)...
- Description
Previous study showed that PIM1 phosphorylates the androgen receptor (AR), the primary therapeutic target in prostate cancer. This study examined the mechanism how PIM1 phosphorylation of AR alters its transcriptional activity. They identified the AR co-activator, 14-3-3 ζ, as an endogenous PIM1 substrate in LNCaP cells. Rapid immunoprecipitation and mass spectrometry of endogenous proteins on chromatin...
- Subject
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CancerGenomicsProteomics
- Access Rights
- Free to All
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NYU Dataset
NR2F2 Isoform Unleashes a Metastatic Program in Melanoma
- Authors
- Veronica DavalosClaudia D. LovellRichard Von ItterIgor Dolgalev17 more author(s)...
- Description
This study described DNA methylation changes that accompany metastatic progression in melanoma patients and found localized methylation changes in the regulatory region of NR2F2. NR2F2 is an orphan-nuclear receptor that is essential for embryonic and neural crest cell (NCC) development. For this study, they examined DNA methylation profiles of NCCs and melanocytes as well as melanoma patient tissues...
- Subject
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CancerGenomics
- Access Rights
- Free to All
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NYU Dataset
Transcription Factor RORα Enforces Stability of the Th17 Cell Effector Program
- Authors
- Jason A. HallMaria PokrovskiiLina KroehlingBo-Ram Kim4 more author(s)...
- Description
The transcription factor RORγt is important for T helper 17 (Th17) cell differentiation. This study examined the role of the closely-related RORα in regulating the Th17 effector program. For the study, mouse T cells were purified from lymph nodes and spleens of six to eight week old mice. The dataset includes RNA sequencing analysis of ex vivo Th17 cells from draining lymph nodes or spinal cords of...
- Subject
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Genomics
- Access Rights
- Free to All
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NYU Dataset
Elongin A Regulates Transcription In Vivo Through Enhanced RNA Polymerase Processivity
- Authors
- Yating WangLiming HouM. Behfar ArdehaliRobert E. Kingston1 more author(s)...
- Description
Elongin, an RNA polymerase II (RNAPII)-associated factor, has shown to stimulate transcriptional elongation in vitro. The Elongin complex is assumed to be required for transcriptional induction in response to cellular stimuli. However, the role of this complex during transcription has not been studied in vivo. This study performed comprehensive studies of the role of Elongin A, the largest subunit...
- Subject
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GenomicsProteomics
- Access Rights
- Free to All
