NYU Data Catalog

NYU Dataset

Authors: Jessica E. Chukwu

Erin E. Congdon

Einar M. Sigurdsson

Xiang-Peng Kong
Description: Tau is one of the major microtubule-associated proteins in neurons. Its main role is to stabilize microtubules, supporting cytoskeletal organization, and axonal transport. Tau may undergo pathological modifications and become hyperphosphorylated. This causes the protein to accumulate into toxic assemblies that collectively lead to neurodegeneration. In Alzheimer's disease, tau proteins change shape...
Subject: Neuroscience

Proteomics
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NYU Dataset

Authors: Marie I. Samanovic

Amber R. Cornelius

Sophie L. Gray-Gaillard

Joseph Richard Allen

7 more author(s)...
Description: To study and compare longitudinal immune responses to two-dose BNT162b2 mRNA vaccinations, investigators recruited 15 adults with a history of laboratory-confirmed COVID-19 and 21 adults who did not have COVID-19. Participants' ages ranged from 21 to 65 years old. Peripheral immune responses were assessed via blood samples drawn before and after each vaccine dose. A total of five samples were collected...
Subject: COVID-19

Infectious Disease
Timeframe: 2021
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NYU Dataset

Authors: Maria M. Steele

Ian D. Dryg

Dhaarini Murugan

Julia Femel

6 more author(s)...
Description: CD8+ T cell accumulation in tumors is essential for effective immunotherapy. However, the mechanisms of lymphocyte transit are still unclear. This study examined lymphatic vessel-mediated effector CD8+ T cell exit limits the accumulation of a broad repertoire of functional CD8+ T cells that improve tumor control in combination with immune checkpoint blockade. They showed that tumor-associated lymphatic...
Subject: Cancer

Genomics
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NYU Dataset

Authors: Taylor A. Heim

Ziyan Lin

Maria M. Steele

Tenny Mudianto

1 more author(s)...
Description: Resident memory T cells (TRM) provide localized protection due to their position in barrier tissues. However, interstitial signals necessary for their formation and persistence are not properly understood. This study demonstrated that antigen-dependent induction of the chemokine receptor, CXCR6, is a conserved requirement for TRM formation in peripheral tissue after viral infection. They used cutaneous...
Subject: Genomics
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NYU Dataset

Authors: Taylor A. Heim

Austin C. Schultz

Ines Delclaux

Vanessa Cristaldi

2 more author(s)...
Description: Resident memory T cells (TRM) provide localized protection in peripheral tissues to pathogens and cancer. However, how they develop during primary infection and their functional significance still remains unclear. This study observed the anatomical distribution of anti-viral CD8+ T cells as they simultaneously seed skin and lymph nodes (LN) TRM. They used a model of skin infection with restricted antigen...
Subject: Genomics
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NYU Dataset

Authors: Mark Yarmarkovich

Quinlen F. Marshall

John M. Warrington

Rasika Premaratne

24 more author(s)...
Description: This study demonstrated that the neuroblastoma immunopeptidome is enriched with peptides derived from proteins essential for tumorigenesis. They targeted the unmutated peptide QYNPIRTTF discovered on HLA-A*24:02, which is derived from the neuroblastoma-dependency gene and master transcriptional regulator PHOX2B. To target QYNPIRTTF, they developed peptide-centric chimeric antigen receptors (PC-CARs)...
Subject: Cancer

Proteomics
Access Rights: Free to All