The Colchicine Coronavirus SARS-CoV2 Trial (COLCORONA) was an international randomized double-blind controlled trial which investigated whether short-term treatment with colchicine decreased the rate of death, rate of hospitalization, and need for medical intervention among adult patients recently diagnosed with COVID-19. A secondary objective was to determine the safety of the intervention among a...

This study characterized gut microbiome in pre-treatment stool using 16S rRNA gene and shotgun metagenome sequencing in melanoma patients undergoing immunotherapy. Transcriptional expression of metagenomic pathways was confirmed with metatranscriptome sequencing. They also examined associations of taxa and metagenomic pathways with progression-free survival (PFS). This dataset contains 16S rRNA gene...

Fragile X syndrome (FXS) is caused by changes in FMR1 gene, which leads to transcriptional silencing and loss of its protein product fragile X mental retardation protein (FMRP). For this study, proteomic experiments were performed to investigate the de novo translational profile in FXS model mice is altered at steady state and in response to metabotropic glutamate receptor (mGluR) stimulation. Altered...

Previous human studies suggest that the cingulate cortex is engaged under difficult listening conditions and may exert top-down modulation of the auditory cortex. Therefore, this study investigated whether the jird cingulate cortex sends anatomical projections to the auditory cortex that facilitate perceptual performance. To model challenging listening conditions, a sound discrimination task was used...

This dataset was collected to show that there is a decline in cytotoxic T cells and TCR clonality in organ transplant recipients (OTRs) with squamous cell carcinoma (SCC). In this study, 5 SCC tumor samples and 6 transplant-associated SCC (TSCC) tumor samples were analyzed. Among SCC samples, the male to female ratio was 3 to 2 and the mean patient age was 81 years. Among TSCC samples, the male to...

To investigate whether acute SARS‐CoV‐2 infection was associated with (1) amyloidogenic, aggregation‐prone forms of αSyn in the cerebrospinal fluid (CSF), (2) signature of pathogenic changes, and (3) future risk for frank synucleinopathy, the research team compared CSF biomarkers obtained through lumbar puncture for the evaluation of neurologic symptoms from 12 adult patients hospitalized at NYU Langone...

The investigators conducted a bibliometric analysis on academic literature indexed in Web of Science on the topic of vitamin D metabolism gene polymorphisms (vitDMGPs) to understand longitudinal research trends and identify areas for further study. The study scope included publications on vitDMGPs (CYP27B1, CYP24A1, CYP2R1, CYP27A1, CYP2R1, DHCR7/NADSYN1) from 1998 to November 2022. In total, the authors...

This dataset showed that mitovesicles, extracellular vesicles (EVs) of mitochondrial origin, are altered in Down syndrome (DS). Mitochondrial dysfunction is a distinctive feature of aging and neurodegenerative disorders, such as DS and Alzheimer’s disease. For this study, a high-resolution density gradient separation of EVs isolated from murine and human DS and diploid control brains was used. Using...

Although targeted cancer therapies have been successful, their efficacies are limited by the development of resistance driven by clonal evolution within tumors. This study developed a single-cell barcoding approach to comprehensively trace clonal dynamics and capture live lineage-coupled resistant cells for in-depth multi-omics analysis and functional exploration. They showed that heterogeneous clones,...

This dataset contains the following: video recordings of animal behaviors, RNA-seq analysis, in vitro recordings, and fiber photometry recordings for a study on the regulation by the posterior amygdala (PA) of sexual and aggressive behaviors in male mice. The video recordings are of all animal behaviors from two synchronized cameras on the side and top of the cage with frame by frame behavioral annotation...