NYU Dataset
Glucose Transporter 1 is Essential to Maintain Brain Endothelial Cell Homeostasis Under Hyperglycemia Condition
UID: 10755
- Description
Glucose transporter-1 (GLUT1) is known for regulating glucose uptake in brain endothelial cells. This study demonstrated the importance of GLUT1 in preserving brain endothelial cell homeostasis beyond regulating glucose uptake. Bulk RNA sequencing was used to analyze transcriptomic alterations under hyperglycemia and GLUT1 deficiency conditions to elucidate the GLUT1-mediated protective mechanism. Validated small interfering RNA was utilized to suppress Glut1 expression and applied high glucose treatment in human brain microvascular endothelial cells. Following treatment, RNA was isolated to analyze changes in transcriptomic profiles through RNA sequencing.
Access
- Restrictions
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Free to All
- Instructions
- The bulk RNA sequencing data in this study are publicly available in Gene Expression Omnibus (GEO).
- Grant Support
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