Preconfigured Dynamics in the Hippocampus Are Guided by Embryonic Birthdate and Rate of Neurogenesis

The hippocampus plays a crucial role in the rapid encoding and storage of episodic memories. This study demonstrated that hippocampal network dynamics are affected by sequential neurogenesis. For the study, they birthdated CA1 pyramidal neurons with in utero electroporation over 4 embryonic days, encompassing the peak of hippocampal neurogenesis, and compared their functional features in freely moving adult mice. This dataset contains electrophysiology and behavioral data. The data indicate that sequential neurogenesis during embryonic development shapes the preconfigured forms of adult network dynamics.