NYU Dataset
Dietary Thiols Accelerates Aging of Caenorhabditis elegans
Part of: Nudler Lab |
UID: 10645
- Description
Glutathione (GSH) and its precursor, N-acetylcysteine (NAC), are common thiol antioxidants, which are among the most popular dietary supplements. However, the long-term effects of GSH or NAC on healthy animals have not been properly studied. This study examined the effects of prolonged supplementation and chronic restriction of GSH and NAC on Caenorhabditis elegans physiology and lifespan. For RNA interference (RNAi) experiments, eggs were isolated and allowed to develop and grow for two generations on specific RNAi expressing bacterial strains before being used for lifespan analyses. This dataset contains RNA sequencing data. The data indicates that it is important for healthy individuals to avoid excessive dietary antioxidants.
Fibroblasts
Associated Publications
Data Type
Equipment Used
Software Used
Access
- Restrictions
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Free to All
- Instructions
- RNA sequencing data generated in this study have been deposited to NCBI's BioProject. Source data are provided with this paper on PubMed Central (PMC) under Supplementary Materials and code for RNA sequencing data processing and differential expression analysis is available on GitHub.
- Grant Support
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Howard Hughes Medical Institute/Howard Hughes Medical InstituteBlavatnik Family Foundation/Blavatnik Family Foundation19-74-30007/Russian Science Foundation17-74-30030/Russian Science FoundationGlenn Foundation for Medical Research/Glenn Foundation for Medical Research
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