The function of hippocampal sharp-wave ripples (SPW-Rs) relate to the consolidation of recent experiences and planning of future actions. This study investigated the impact of SPW-Rs on the firing patterns of lateral septal (LS) neurons in behaving rats. The experiments were performed on Long-Evans rats. For this study, they examined the hippocampal-LS circuit by simultaneously recording activity patterns of the hippocampus and LS. Each recording consisted of three periods of time recorded continuously: pre-behavior home cage, maze traversal, and post-behavior home cage. The dataset contains behavioral, electrophysiology, and immunohistochemistry data. The data indicate that LS is strongly activated by SPW-Rs and hippocampal sharp wave ripple-related bursts are routed to subcortical structures through the lateral septum.