Bilateral Medial Entorhinal Cortex Silencing Causes Remapping in CA1 Cell Assemblies
- Description
The discovery of grid cells in the medial entorhinal cortex (mEC) encouraged investigation of the effect of the mEC on the hippocampus. Large lesions of the entorhinal cortex reduced theta oscillations, decreased the fraction of hippocampal CA1 place cells, and affected various features of place field properties. This study performed combined optogenetic and pharmacogenetic local and upstream inactivation in the hippocampus. For this study, C57BL/6 mice were used in all experiments. The dataset contains behavioral, electrophysiology, and immunohistochemistry data. The data showed that the CA1 network can induce and maintain coordinated cell assemblies with minimal reliance on its inputs. However, these inputs can effectively reconfigure and assist in maintaining stability of the CA1 map.
Access
- Restrictions
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Free to All
- Instructions
- The data of this study are publicly available in the Buzsaki Lab Webshare. All custom code for preprocessing the data and scripts specific for analyzing this dataset can be found on GitHub.
- Grant Support
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1707316/NSFLeon Levy Fellowship in Neuroscience/Leon Levy Foundation