Hippocampus has been involved in both cognitive and endocrine functions. This study measured electrophysiological activity from the hippocampus and interstitial glucose concentrations in the body of freely behaving rats to identify an activity pattern that may link these disparate functions of the hippocampus. For this study, they used adult Long Evans rats. During the experiment, rats were recorded continuously for up to 7 days in the modified home cage. The dataset includes interstitial glucose concentrations and electrophysiology data. The data showed that a function of the sharp wave-ripple is to modulate peripheral glucose homeostasis. This offers a mechanism for the link between sleep disruption and blood glucose dysregulation in type 2 diabetes.