Electrophysiological Activity and Interstitial Glucose Concentrations Links Disparate Functions of the Hippocampus

Hippocampus has been involved in both cognitive and endocrine functions. This study measured electrophysiological activity from the hippocampus and interstitial glucose concentrations in the body of freely behaving rats to identify an activity pattern that may link these disparate functions of the hippocampus. For the study, an amperometric glucose monitor was used to continuously measure glucose concentrations in interstitial fluid and electrophysiological signals were recorded from the dorsal hippocampal CA1 region of Long Evans rats. The dataset includes interstitial glucose concentrations and electrophysiology data. This study offers a mechanism for the link between sleep disruption and blood glucose dysregulation in type 2 diabetes.