Description

Smoldering multiple myeloma (SMM) is an asymptomatic plasma cell disorder, which is associated with a high-risk of progression to multiple myeloma (MM). For this study, they performed targeted sequencing of CD138+ cells in bone marrow and peripheral blood collected from 82 patients from the University of Arkansas for Medical Science. The investigators also analyzed the change in clonal structure over time by examining 53 samples collected at multiple time points from nine patients. This dataset contains targeted panel and whole exome sequencing data. The publication also contains supplementary data, which includes several tables on incidence of copy number changes in SMM and MM based on copy number estimates from the targeted panel, summary of sample sequencing metrics, a list of genes on the targeted panel, metrics of sequential samples, ddPCR primer and probe sequences, and a list of loci included in the plot comparing SMM and MM copy number changes.

Geographic Coverage
Arkansas
Subject of Study
Subject Domain
Population Age
Adult (19 years - 64 years)
Senior (65 years - 79 years)
Aged (80 years and over)
Keywords

Access

Restrictions
Free to All
Author Approval Required
Instructions
Targeted panel and whole exome sequencing data have been deposited to the European Genome-Phenome Archive (EGA). These data are available under restricted access and access can be obtained by contacting Gareth Morgan, MD, PhD through the EGA data repository. All other data are available within the article on PubMed Central (PMC) under Supplementary Materials.
Access via EGA

Targeted panel data
Accession #: EGAD00001005056

Access via EGA

Whole exome sequencing
Accession #: EGAD00001005285

Access via PMC

Supplementary data
Accession #: PMC7804406

Associated Publications
Data Type
Equipment Used
AutoMACS Pro Separator
Illumina NextSeq 500
QX200 Droplet Reader
RoboSep
Software Used
BWA v0.7.12
Control-FREEC v3.0.0
FPfilter
Manta v0.29.6
NMF
QuantaSoft v1.7.4
Sequenza v3.0.0
Strelka v1.0.14
Variant Effect Predictor v85
Study Type
Observational
Grant Support
Multiple Myeloma Research Foundation/Multiple Myeloma Research Foundation
Perelman Family Foundation/Perelman Family Foundation
6020- 20/Leukemia & Lymphoma Society
Federation Francaise de Recherche sur le Myelome et les Gammapathies/Fondation de France