Whole Exome Sequencing Confirmed Progression of Smoldering Multiple Myeloma to Multiple Myeloma
- Description
Smoldering multiple myeloma (SMM) is an asymptomatic plasma cell disorder. It is associated with a high-risk of progression to multiple myeloma (MM). For this study, they performed targeted sequencing on 82 patients. The results showed fewer NRAS and FAM46C mutations with SMM, which is consistent with their role as drivers of the transition to MM. They also analyzed the change in clonal structure over time, where they examined 53 samples from nine patients at multiple time points.
This study includes whole exome sequencing and targeted panel data. The publication also contains supplementary data, which includes several tables. The tables contain data about incidence of copy number changes in SMM and MM based on copy number estimates from the targeted panel, summary of sample sequencing metrics, list of genes on the targeted panel, metrics of sequential samples, ddPCR primer and probe sequences, and list of loci included in the plot comparing SMM and MM copy number changes.
Access
- Restrictions
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Free to AllAuthor Approval Required
- Instructions
- The targeted panel data and whole exome sequencing are deposited in the EGA database. These data are available under restricted access and access can be obtained by contacting Gareth Morgan via the EGA database. The remaining data are available within the article in the Supplementary Materials.
- Grant Support
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Multiple Myeloma Research Foundation/Multiple Myeloma Research FoundationPerelman Family Foundation/Perelman Family Foundation6020- 20/Leukemia & Lymphoma SocietyFederation Francaise de Recherche sur le Myelome et les Gammapathies/Fondation de France