NYU Dataset
Sequencing Data for a Delta-Omicron Recombinant in an Immunosuppressed Transplant Recipient Treated with Monoclonal Antibody Sotrovimab
UID: 10454
- Description
- A Delta-Omicron recombinant of the SARS-CoV-2 virus was sequenced and isolated from an immunosuppressed and unvaccinated male kidney transplant patient who received Sotrovimab for treatment of COVID-19. Further clinical details and medical history of the patient are described in the associated publication. Sotrovimab is a therapeutic monoclonal antibody (mAb) used to treat infections by the BA.1 Omicron lineage. It was observed that the Delta-Omicron recombinant found in this patient was resistant to neutralization by Sotrovimab. Genomic analysis of the SARS-CoV-2-positive nasopharyngeal swab specimen revealed an unusual SARS-CoV-2 sequence with outlier Omicron BA.1 placement in a global phylogenetic tree and high number of mutations.
- Timeframe
- 2022
Access
- Restrictions
-
Free to AllApplication Required
- Instructions
- A GISAID account is required to access the sequencing data shared in the GISAID repository. Users must complete a Database Access Agreement and Registration Form to obtain credentials. Raw FASTQ files have been shared in the Sequence Read Archive (SRA), accessible through BioProject.
Observational
- Grant Support
-
G0E1420N/Research Foundation - FlandersG098321N/Research Foundation - FlandersC14/18/094/Internal Funds KU LeuvenNU50CK000516/CDCV420922N/Research Foundation FlandersJan Vilcek/David Goldfarb Fellowship Endowment Fund/NYU Langone Health
- Other Resources
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ncov2019-artic-nf Pipeline
Consensus genome
SWISS-MODELFully automated protein structure homology-modelling server
UShERUltrafast Sample placement on Existing tRee
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