NYU Data Catalog

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  • NYU Dataset

    Genomic data for the testing of gold-standard networks of direct regulatory interactions in Saccharomyces cerevisiae

    Authors
    Sisi Ma
    Alexander Statnikov
    Description

    This data was created and compiled as researchers built genome-scale gold-standard networks of direct regulatory interactions in Saccharomyces cerevisiae that incorporate binding and gene knockout data. The research team used seven performance measurements to see the accuracy of eighteen statistics association-based approaches for de-novo network reverse-engineered in 13 different datasets spanning...

    Subject
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    Gene Expression and Transcription Factors are Modified in Human Keratinocytes Exposed to Solar Simulated Ultraviolet Radiation

    Authors
    Thomas L. Des Marais
    Thomas Kluz
    Dazhong Xu
    Xiaoru Zhang
    4 more author(s)...
    Description

    Ultraviolet radiation (UVR) from the sun is the major cause of skin cancer. However, genes and pathways altered by solar-simulated UVR (ssUVR), a mixture of UVA and UVB, still remains unclear. For this study, human HaCaT keratinocytes were exposed to a single dose or 5 repetitive doses of ssUVR. Analyses of gene expression profiles and functional annotation were performed at 24 hours after irradiation....

    Subject
    Cancer
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    Transcription Factor RORα Enforces Stability of the Th17 Cell Effector Program

    Authors
    Jason A. Hall
    Maria Pokrovskii
    Lina Kroehling
    Bo-Ram Kim
    4 more author(s)...
    Description

    The transcription factor RORγt is important for T helper 17 (Th17) cell differentiation. This study examined the role of the closely-related RORα in regulating the Th17 effector program. For the study, mouse T cells were purified from lymph nodes and spleens of six to eight week old mice. The dataset includes RNA sequencing analysis of ex vivo Th17 cells from draining lymph nodes or spinal cords of...

    Subject
    Genomics
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    Free to All
  • NYU Dataset

    Genome-Wide Aryl Hydrocarbon Receptor-DNA Binding Reveal Tissue-Specific Binding Determinants

    Authors
    David Filipovic
    Wenjie Qi
    Omar Kana
    Daniel Marri
    4 more author(s)...
    Description

    Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor whose ligands include the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Ligand-activated AhR binds to DNA at dioxin response elements (DREs). Most DREs in accessible chromatin are not bound by TCDD-activated AhR, and DREs accessible in multiple tissues can be bound in some and unbound in others. This...

    Subject
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    Genome-Wide Screening Identifies Trim33 as an Essential Regulator of Dendritic Cell Differentiation

    Authors
    Ioanna Tiniakou
    Pei-Feng Hsu
    Lorena S. Lopez-Zepeda
    Gorkem Garipler
    16 more author(s)...
    Description

    The development of dendritic cells (DCs) are controlled by the growth factor Flt3 ligand (Flt3L) and its receptor Flt3. This study contained in vitro CRISPR/Cas9-based dropout genetic screening of DC differentiation from HoxB8-FL cells, in vitro validation of the inhibition of mammalian target of rapamycin (mTOR) signaling as a requirement for HoxB8-FL differentiation, and in vivo validation of select...

    Subject
    Genomics
    Access Rights
    Free to All