NYU Data Catalog

NYU Dataset

Authors: Sisi Ma

Alexander Statnikov
Description: This data was created and compiled as researchers built genome-scale gold-standard networks of direct regulatory interactions in Saccharomyces cerevisiae that incorporate binding and gene knockout data. The research team used seven performance measurements to see the accuracy of eighteen statistics association-based approaches for de-novo network reverse-engineered in 13 different datasets spanning...
Subject: Genomics
Access Rights: Free to All

NYU Dataset

Authors: Thomas L. Des Marais

Thomas Kluz

Dazhong Xu

Xiaoru Zhang

4 more author(s)...
Description: Ultraviolet radiation (UVR) from the sun is the major cause of skin cancer. However, genes and pathways altered by solar-simulated UVR (ssUVR), a mixture of UVA and UVB, still remains unclear. For this study, human HaCaT keratinocytes were exposed to a single dose or 5 repetitive doses of ssUVR. Analyses of gene expression profiles and functional annotation were performed at 24 hours after irradiation....
Subject: Cancer

Genomics
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NYU Dataset

Authors: Jason A. Hall

Maria Pokrovskii

Lina Kroehling

Bo-Ram Kim

4 more author(s)...
Description: The transcription factor RORγt is important for T helper 17 (Th17) cell differentiation. This study examined the role of the closely-related RORα in regulating the Th17 effector program. For the study, mouse T cells were purified from lymph nodes and spleens of six to eight week old mice. The dataset includes RNA sequencing analysis of ex vivo Th17 cells from draining lymph nodes or spinal cords of...
Subject: Genomics
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NYU Dataset

Authors: David Filipovic

Wenjie Qi

Omar Kana

Daniel Marri

4 more author(s)...
Description: Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor whose ligands include the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Ligand-activated AhR binds to DNA at dioxin response elements (DREs). Most DREs in accessible chromatin are not bound by TCDD-activated AhR, and DREs accessible in multiple tissues can be bound in some and unbound in others. This...
Subject: Genomics
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NYU Dataset

Authors: Ioanna Tiniakou

Pei-Feng Hsu

Lorena S. Lopez-Zepeda

Gorkem Garipler

16 more author(s)...
Description: The development of dendritic cells (DCs) are controlled by the growth factor Flt3 ligand (Flt3L) and its receptor Flt3. This study contained in vitro CRISPR/Cas9-based dropout genetic screening of DC differentiation from HoxB8-FL cells, in vitro validation of the inhibition of mammalian target of rapamycin (mTOR) signaling as a requirement for HoxB8-FL differentiation, and in vivo validation of select...
Subject: Genomics
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NYU Dataset

Authors: Hongsu Wang

Komal Kumar Bollepogu Raja

Kelvin Yeung

Carolyn A. Morrison

8 more author(s)...
Description: This study demonstrated that synergistic activation by two transcription factors, Pointed (Pnt) and Glass (Gl), drives a program of neuronal gene expression in developing Drosophila photoreceptors. Differentiation of photoreceptors R1–R7 requires epidermal growth factor (EGFR) signaling. The intrinsic zinc finger transcription factor Gl is expressed in all eye disc cells beginning just prior to their...
Subject: Genomics
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NYU Dataset

Authors: Begum Aydin

Michael Sierk

Mireia Moreno-Estelles

Link Tejavibulya

4 more author(s)...
Description: Transcription factors (TFs) are the key players controlling transcriptional activity during cell-type specification. In recent years, reprogramming, direct programming, and transdifferentiation experiments have taken advantage of this principle to impose cell type-specific gene regulatory programs. This study examined the contribution of a series of TFs to specific neuronal regulatory programs using...
Subject: Genomics
Access Rights: Free to All