NYU Data Catalog

Filter by

of 1 Next >
Results Found: 7
  • NYU Dataset

    Physician Decision-Making During Active Surveillance of Prostate Cancer

    Authors
    Stacy Loeb
    Caitlin E. Curnyn
    Angela Fagerlin
    R. Scott Braithwaite
    4 more author(s)...
    Description

    This dataset includes structured, in-depth interviews with 24 physicians from diverse clinical backgrounds and geographic areas within the United States. These physicians were identified with purposive sampling strategies. Physicians who reported currently caring for patients through active surveillance were invited to participate. An interview guide was developed based on a literature review and previous...

    Subject
    Cancer
    Health Care System
    Timeframe
    2015
    Access Rights
    Application Required
    Author Approval Required
  • NYU Dataset

    fastMRI

    Authors
    Florian Knoll
    Patricia M. Johnson
    Daniel K. Sodickson
    Michael P. Recht
    1 more author(s)...
    Description

    This deidentified imaging dataset is comprised of raw k-space data in several sub-dataset groups. Raw and DICOM data have been deidentified via conversion to the vendor-neutral ISMRMRD format and the RSNA Clinical Trial Processor, respectively. Manual inspection of each DICOM image was also performed to check for the presence of any unexpected protected health information (PHI), with spot checking...

    Subject
    Anatomy
    Cancer
    Access Rights
    Free to All
    Application Required

  • Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial Datasets

    Alternate Title(s)
    PLCO
    Description

    The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial was a large randomized controlled trial that assessed whether certain screening practices decreased deaths from prostate, lung, colorectal and ovarian cancer. Approximately 155,000 men and women aged 55 to 74 years old were enrolled from 10 screening centers across the United States between November 1993 and July 2001. Participants...

    Subject
    Cancer
    Chronic Disease
    Health Care System
    Access Rights
    Application Required
    Local Expert
    Richard B. Hayes
  • NYU Dataset

    RNA Immunoprecipitation Sequencing Reveals ORF1p Association with Prostate Cancer

    Authors
    Erica M. Briggs
    Wilson McKerrow
    Paolo Mita
    Jef D. Boeke
    2 more author(s)...
    Description

    Long interspersed element-1 (LINE-1) is an autonomous retroelement that utilizes copy and paste mechanism to propagate themselves throughout the genome through a process called retrotransposition. The LINE-1 bicistronic mRNA codes for two proteins, ORF1p and ORF2. While LINE-1 transcription is usually repressed in most healthy somatic cells, ORF1p expression has been observed in tumors, including prostate...

    Subject
    Cancer
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    PIM1 Phosphorylation Regulates Gene Transcription in Prostate Cancer

    Authors
    Sophie E. Ruff
    Nikita Vasilyev
    Evgeny Nudler
    Susan K. Logan
    1 more author(s)...
    Description

    Previous study showed that PIM1 phosphorylates the androgen receptor (AR), the primary therapeutic target in prostate cancer. This study examined the mechanism how PIM1 phosphorylation of AR alters its transcriptional activity. They identified the AR co-activator, 14-3-3 ζ, as an endogenous PIM1 substrate in LNCaP cells. Rapid immunoprecipitation and mass spectrometry of endogenous proteins on chromatin...

    Subject
    Cancer
    Genomics
    Proteomics
    Access Rights
    Free to All
  • NYU Dataset

    Identification of PIM1 Substrates Reveals a Role for NDRG1 Phosphorylation in Prostate Cancer

    Authors
    Russell J. Ledet
    Sophie E. Ruff
    Yu Wang
    Shruti Nayak
    4 more author(s)...
    Description

    This study performed a chemical genetic screen to identify PIM1 substrates in prostate cancer cells. They identified 25 previously unknown PIM1 substrates and their phosphorylation sites. Among the identified PIM1 substrates, N-Myc Downstream-Regulated Gene 1 (NDRG1) was shown to be as an inhibitor of metastasis. The study demonstrated that PIM1 phosphorylation of NDRG1 reduced its stability, nuclear...

    Subject
    Cancer
    Proteomics
    Access Rights
    Free to All
  • NYU Dataset

    Mapping the Landscape of Histomorphological Cancer Phenotypes Using Self-Supervised Learning on Unannotated Pathology Slides

    Authors
    Adalberto Claudio Quiros
    Nicolas Coudray
    Anna H. Yeaton
    Xinyu Yang
    12 more author(s)...
    Description

    Histomorphological Phenotype Learning (HPL) was developed as a self-supervised methodology to discriminatory features in microscopy images to aid in cancer diagnosis and management. The methodology partitions whole slide images (WSIs) into meaningful Histomorphological Phenotype Clusters (HPCs) that can be used to define and quantify morphological phenotypes which recur within and between cases. HPL...

    Subject
    Cancer
    Chronic Disease
    Access Rights
    Free to All
    Author Approval Required