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NYU Dataset
fastMRI
- Authors
- Florian KnollPatricia M. JohnsonDaniel K. SodicksonMichael P. Recht1 more author(s)...
- Description
This deidentified imaging dataset is comprised of raw k-space data in several sub-dataset groups. Raw and DICOM data have been deidentified via conversion to the vendor-neutral ISMRMRD format and the RSNA Clinical Trial Processor, respectively. Manual inspection of each DICOM image was also performed to check for the presence of any unexpected protected health information (PHI), with spot checking...
- Subject
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AnatomyCancer
- Access Rights
- Free to AllApplication Required
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NYU Dataset
Identification of PIM1 Substrates Reveals a Role for NDRG1 Phosphorylation in Prostate Cancer
- Authors
- Russell J. LedetSophie E. RuffYu WangShruti Nayak4 more author(s)...
- Description
This study performed a chemical genetic screen to identify PIM1 substrates in prostate cancer cells. They identified 25 previously unknown PIM1 substrates and their phosphorylation sites. Among the identified PIM1 substrates, N-Myc Downstream-Regulated Gene 1 (NDRG1) was shown to be as an inhibitor of metastasis. The study demonstrated that PIM1 phosphorylation of NDRG1 reduced its stability, nuclear...
- Subject
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CancerProteomics
- Access Rights
- Free to All
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NYU Dataset
MPC309 Modulates Androgen Receptor Transcriptional Activity to Inhibit Therapy-Resistant Prostate Cancer
- Authors
- Justine HabaultJeffrey A. SchneiderSusan HaRachel Ruoff14 more author(s)...
- Description
Prostate cancer cells depend on the androgen receptor (AR) for survival and proliferation. This study examined the antitumor effects of compound MPC309, a trivalent display of ethisterone conjugated to a peptoid oligomer backbone that binds to the AR with nanomolar affinity. First, a structure-activity relationship study was performed to improve multivalent peptoid conjugate potency. Then, the impact...
- Subject
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CancerGenomics
- Access Rights
- Free to All
