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  • NYU Dataset

    Identifying Behavioral Links to Neural Dynamics of Multifiber Photometry Recordings

    Authors
    Yibo Chen
    Jonathan Chien
    Bing Dai
    Dayu Lin
    1 more author(s)...
    Description

    The hypothalamic-midbrain neural circuits play an important role in social interactions involving aggression, defense, and mating. However, how population-averaged neural activity measured by multi-fiber photometry (MFP) for calcium fluorescence signals correlates with social behaviors is a fundamental question. This study proposed a state-space analysis framework to characterize mouse MFP data based...

    Subject
    Neuroscience
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    Free to All
  • NYU Dataset

    A Dedicated Hypothalamic Oxytocin Circuit Controls Aversive Social Learning

    Authors
    Takuya Osakada
    Rongzhen Yan
    Yiwen Jiang
    Dongyu Wei
    9 more author(s)...
    Description

    Fighting is a major means to compete for limited resources in the wild. After the fight ends, the loser continuously avoids close interaction with the winner and readily flees when confronted. The neural mechanisms that underlie the rapid and long-lasting behavioral changes induced by defeat remains unclear. This study identified oxytocin neurons in the retrochiasmatic supraoptic nucleus and oxytocin-receptor-expressing...

    Subject
    Neuroscience
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    Free to All
  • NYU Dataset

    Hypothalamic Pathway Suppresses Aggression Toward Superior Opponents

    Authors
    Dongyu Wei
    Takuya Osakada
    Zhichao Guo
    Takashi Yamaguchi
    4 more author(s)...
    Description

    Aggression is an innate social behavior and aggression directed toward a stronger opponent in animals can lead to severe physical damage or even death. Therefore, disadvantageous fights to survive and reproduce need to be avoided. This study identified the projection from estrogen receptor alpha-expressing cells in the caudal part of the medial preoptic area (cMPOAEsr1) to the ventrolateral part of...

    Subject
    Neuroscience
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    Free to All
  • NYU Dataset

    VMHvllCckar Cells Dynamically Control Female Sexual Behaviors

    Authors
    Luping Yin
    Koichi Hashikawa
    Yoshiko Hashikawa
    Takuya Osakada
    3 more author(s)...
    Description

    The ventrolateral part of ventromedial hypothalamus (VMHvl) is an important locus for controlling female sexual behaviors. This study identified the cholecystokinin A receptor (Cckar) expressing cells in the lateral VMHvl (VMHvllCckar) as key controllers for female sexual behaviors. They generated a CckarCre knock-in mouse line to target Cckar expressing cells. In addition, they introduced a highly...

    Subject
    Neuroscience
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    Application Required
    Author Approval Required
  • NYU Dataset

    Dopamine Responses and Functions in Nucleus Accumbens Core During Social Behaviors

    Authors
    Bing Dai
    Fangmiao Sun
    Xiaoyu Tong
    Yizhuo Ding
    4 more author(s)...
    Description

    Social behaviors are among the most notable motivated behaviors that are driven by rewarding goals. However, how dopamine (DA), a reward signal, releases during social behaviors has been unclear. This study used a genetically encoded DA sensor, GRABDA2m, to record DA activity in the nucleus accumbens (NAc) core during various social behaviors in male and female mice. They performed optical recording...

    Subject
    Neuroscience
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    Application Required
    Author Approval Required