Locus Coeruleus Activity Improves Cochlear Implant Performance
- Description
Cochlear implant use require neuroplasticity within the central auditory system. Despite extensive studies on how cochlear implants activate the auditory system, understanding of cochlear implant-related neuroplasticity remains unknown. This study investigated behavioral responses and neural activity in locus coeruleus and auditory cortex of deafened rats fitted with multi-channel cochlear implants. For this study, Long-Evans or TH-Cre rats were used for all experiments. Animals were trained on a reward-based auditory task, with considerable individual differences of learning rates and maximum performance. The dataset contains behavioral, fiber photometry, immunohistochemistry, and electrophysiology data. The data indicate that adequate engagement of central neuromodulatory systems is a clinically-relevant target for optimizing neuroprosthetic device use.
Access
- Restrictions
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Free to All
- Instructions
- The data that support the findings of this study are available on Zenodo and custom code used in this study is available on GitHub. Source data are provided with this paper on PubMed Central (PMC) under Supplementary Materials.
- Grant Support
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Sloan Research Fellowship/Alfred P. Sloan FoundationIrma T. Hirschl/Monique Weill-Caulier Research Award/Irma T. Hirschl/Monique Weill-Caulier Research AwardCochlear Limited/Cochlear LimitedVilcek Scholar/Vilcek Scholarship
- Other Resources
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NITRC
Waxholm space atlas of the Sprague Dawley rat brain