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NYU Dataset
Lymphatic Vessels Limits the Intratumoral T cell Repertoire in Melanoma
- Authors
- Maria M. SteeleAbhinav JaiswalInes DelclauxIan D. Dryg10 more author(s)...
- Description
CD8+ T cell accumulation in tumors is essential for effective immunotherapy. However, the mechanisms of lymphocyte transit are still unclear. This study examined lymphatic vessel-mediated effector CD8+ T cell egress limits the accumulation of a broad repertoire of functional CD8+ T cells. To investigate the transcriptional changes in lymphatic endothelial cells (LECs) during tumor development, RNA...
- Subject
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CancerGenomics
- Access Rights
- Free to All
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NYU Dataset
Lymphatic Vessel Transit Seeds Cytotoxic Resident Memory T Cells in Skin Draining Lymph Nodes
- Authors
- Taylor A. HeimAustin C. SchultzInes DelclauxVanessa Cristaldi3 more author(s)...
- Description
Resident memory T cells (TRM) provide localized protection in peripheral tissues to pathogens and cancer. However, how they develop during primary infection and their functional significance remains unclear. This study observed the anatomical distribution of anti-viral CD8+ T cells as they simultaneously seed skin and lymph nodes TRM. To determine transcriptional differences between cells in the draining...
- Subject
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Genomics
- Access Rights
- Free to All
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NYU Dataset
CXCR6 Promotes Dermal CD8+ T Cell Survival and Transition to Long-Term Tissue Residence
- Authors
- Taylor A. HeimOchapa IbrahimZiyan LinAustin C. Schultz3 more author(s)...
- Description
Resident memory T cells (TRM) provide localized protection due to their position in barrier tissues. However, interstitial signals necessary for their formation and persistence are not properly understood. This study demonstrated that antigen-dependent induction of the chemokine receptor, CXCR6, is a conserved requirement for TRM formation in peripheral tissue after viral infection. Cutaneous murine...
- Subject
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CancerGenomics
- Access Rights
- Free to All