NYU Data Catalog

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  • NYU Dataset

    Lymphatic Vessels Limits the Intratumoral T cell Repertoire in Melanoma

    Authors
    Maria M. Steele
    Ian D. Dryg
    Dhaarini Murugan
    Julia Femel
    6 more author(s)...
    Description

    CD8+ T cell accumulation in tumors is essential for effective immunotherapy. However, the mechanisms of lymphocyte transit are still unclear. This study examined lymphatic vessel-mediated effector CD8+ T cell exit limits the accumulation of a broad repertoire of functional CD8+ T cells that improve tumor control in combination with immune checkpoint blockade. They showed that tumor-associated lymphatic...

    Subject
    Cancer
    Genomics
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  • NYU Dataset

    CXCR6 Promotes Dermal CD8+ T Cell Survival and Transition to Long-Term Tissue Residence

    Authors
    Taylor A. Heim
    Ziyan Lin
    Maria M. Steele
    Tenny Mudianto
    1 more author(s)...
    Description

    Resident memory T cells (TRM) provide localized protection due to their position in barrier tissues. However, interstitial signals necessary for their formation and persistence are not properly understood. This study demonstrated that antigen-dependent induction of the chemokine receptor, CXCR6, is a conserved requirement for TRM formation in peripheral tissue after viral infection. They used cutaneous...

    Subject
    Genomics
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  • NYU Dataset

    Lymphatic Vessel Transit Seeds Precursors to Cytotoxic Resident Memory T Cells in Skin Draining Lymph Nodes

    Authors
    Taylor A. Heim
    Austin C. Schultz
    Ines Delclaux
    Vanessa Cristaldi
    2 more author(s)...
    Description

    Resident memory T cells (TRM) provide localized protection in peripheral tissues to pathogens and cancer. However, how they develop during primary infection and their functional significance still remains unclear. This study observed the anatomical distribution of anti-viral CD8+ T cells as they simultaneously seed skin and lymph nodes (LN) TRM. They used a model of skin infection with restricted antigen...

    Subject
    Genomics
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