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  • NYU Dataset

    Sequencing Data Illustrates Polyadenylation of Histone H3.1 mRNA Promotes Cell Transformation by Displacing H3.3 from Gene Regulatory Elements

    Authors
    Danqi Chen
    Qiao Yi Chen
    Zhenjia Wang
    Yusha Zhu
    12 more author(s)...
    Description

    Previous study showed that exposure to arsenic, an environmental carcinogen, induces polyadenylation of canonical histone H3.1 mRNA. This study revealed that polyadenylation of H3.1 mRNA increases H3.1 protein, which results in displacement of histone variant H3.3 at active promoters, enhancers, and insulator regions. To investigate global changes in transcription induced by ectopic expression of polyadenylated...

    Subject
    Genomics
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  • NYU Dataset

    NOGOB Receptor Deficiency Increases Cerebrovascular Permeability and Hemorrhage

    Authors
    Zhi Fang
    Xiaoran Sun
    Xiang Wang
    Ji Ma
    6 more author(s)...
    Description

    Cerebral cavernous malformation (CCM) lesions are caused by loss of function of CCM genes. Previous study showed that NOGOB receptor (NGBR) knockout in endothelial cells results in cerebrovascular lesions in the mouse embryo. However, the molecular mechanism by which NGBR regulates CCM1/2 expression has not been explained. This study used RNA sequencing analysis to determine the alteration of transcriptomic...

    Subject
    Genomics
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  • NYU Dataset

    PRC1 Sustains the Integrity of Neural Fate in the Absence of PRC2 Function

    Authors
    Ayana Sawai
    Sarah Pfennig
    Milica Bulajic
    Alexander Miller
    3 more author(s)...
    Description

    Polycomb repressive complexes (PRCs) are known for repressing transcription through histone modifications and chromatin compaction. The PRCs consist of two central protein complexes, PRC1 and PRC2, which are important for normal gene regulation and development. This study found that PRC1 is essential for the specification of segmentally restricted spinal motor neuron subtypes, while PRC2 activity is...

    Subject
    Genomics
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    Free to All