NYU Dataset
Sequencing Data Illustrates Polyadenylation of Histone H3.1 mRNA Promotes Cell Transformation by Displacing H3.3 from Gene Regulatory Elements
UID: 10499
- Description
Arsenic, an environmental carcinogen, exposure induces polyadenylation of canonical histone H3.1 mRNA. For this study, human bronchial epithelial cells were exposed to arsenic for in vitro experiments, while A/J mice were exposed to arsenic for in vivo experiments. The results showed that polyadenylation of H3.1 mRNA increases H3.1 protein, which results in displacement of histone variant H3.3 at active promoters, enhancers, and insulator regions. Arsenic exposure also resulted in displacement of H3.3 from active promoters, enhancers, and insulator regions. The dataset contains RNA and ChIP sequencing data. The data indicates that H3.3 displacement leads to carcinogenesis through polyadenylation of H3.1 mRNA upon arsenic exposure.
HEK293 cells
BEAS-2B cells
PZ-HPV-7 cells
A/J mice
Associated Publications
Data Type
Equipment Used
Software Used
Access
- Restrictions
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Free to All
- Instructions
- All sequencing data generated during this study are available at NCBI's Gene Expression Omnibus (GEO) database.
- Grant Support
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