NYU Health Sciences Library NYU Data Catalog
NYU Health Sciences Library NYU Data Catalog
NYU Health Sciences Library Data Catalog

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Results Found: 3
  • NYU Dataset

    Electrophysiological Activity and Interstitial Glucose Concentrations Links Disparate Functions of the Hippocampus

    Authors
    David Tingley
    Kathryn McClain
    Ekin Kaya
    Jordan Carpenter
    1 more author(s)...
    Description

    Hippocampus has been involved in both cognitive and endocrine functions. This study measured electrophysiological activity from the hippocampus and interstitial glucose concentrations in the body of freely behaving rats to identify an activity pattern that may link these disparate functions of the hippocampus. For the study, an amperometric glucose monitor was used to continuously measure glucose concentrations...

    Subject
    Neurosciences
    Access Rights
    Free to All
  • NYU Dataset

    Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl tRNAs Requires SHMT2

    Authors
    Denise R. Minton
    Minwoo Nam
    Daniel J. McLaughlin
    Jong Shin
    7 more author(s)...
    Description

    Eukaryotic cells upregulate oxidative metabolism to maintain homeostasis upon glucose restriction. This study used CRISPR/Cas9-based screening to identify serine catabolic enzyme SHMT2. They found that the mitochondrial SHMT2 is required for robust mitochondrial oxygen consumption and low glucose proliferation. This dataset contains immunoblot images, as well as supplementary data tied to the publication....

    Subject
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    Glucose Transporter 1 is Essential to Maintain Brain Endothelial Cell Homeostasis Under Hyperglycemia Condition

    Authors
    Benjamin Miao
    Mohammad Sarif Mohiuddin
    Rashu Barua
    Md Wahiduzzaman
    6 more author(s)...
    Description

    Glucose transporter-1 (GLUT1) is known for regulating glucose uptake in brain endothelial cells. This study demonstrated the importance of GLUT1 in preserving brain endothelial cell homeostasis beyond regulating glucose uptake. Bulk RNA sequencing was used to analyze transcriptomic alterations under hyperglycemia and GLUT1 deficiency conditions to elucidate the GLUT1-mediated protective mechanism....

    Subject
    Genomics
    Access Rights
    Free to All