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  • NYU Dataset

    Switch-like and persistent memory formation in individual Drosophila larvae

    Authors
    Amanda Lesar
    Javan Tahir
    Jason Wolk
    Marc Gershow
    Description

    Using a Y-shaped maze, several experiments were developed to assess conditions of associative learning among fruit fly larvae. Prior to the start of the experiments, some fruit fly larvae were fed a diet of all-trans-retinal (ATR), which is a co-factor for csChrimson activation (eliciting escape behavior in flies which perceive red light). A subgroup of larvae who were fed ATR also received cycloheximide...

    Subject
    Neuroscience
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  • NYU Dataset

    Behavioral and Electrophysiology Data Indicates Wind Direction is Decoded by Central Neurons in Drosophila

    Authors
    Marie P. Suver
    Andrew M. M. Matheson
    Sinekdha Sarkar
    Matthew Damiata
    2 more author(s)...
    Description

    Wind is a major navigational cue for insects and this study examined how wind direction is decoded by central neurons in the insect brain. They determined that flies combine signals from both antennae to orient to wind during olfactory search behavior. In Drosophila, movements of the antennae are detected by mechanosensory neurons, known as Johnston’s Organ (JO) neurons. The JO neurons project from...

    Subject
    Neuroscience
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  • NYU Dataset

    Electrophysiology and Imaging Data Identified Central Complex Neurons that Encode Airflow Direction in Drosophila

    Authors
    Timothy A. Currier
    Andrew M. M. Matheson
    Katherine I. Nagel
    Description

    This data was collected to identify the brain regions and circuit organizations that support navigation. In insects, the central complex (CX) is thought to control many aspects of navigation. The CX is a highly organized neuropil, which consists of the protocerebral bridge, the ellipsoid body, the fan-shaped body, and the paired noduli. This study contains electrophysiology, imaging, and behavioral...

    Subject
    Neuroscience
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  • NYU Dataset

    Predicting Behavioral Dynamics in Drosophila Using Algorithms

    Authors
    Timothy A. Currier
    Katherine I. Nagel
    Description

    The algorithms used by the nervous system to integrate synergistic and conflicting stimuli across modalities are still under investigation. This study developed a closed-loop orienting paradigm in Drosophila to study the algorithms by which cues from two modalities are integrated during ongoing behavior. In the study, all experiments were performed on adult female flies three to five days after hatching....

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  • NYU Dataset

    Neurons Specify Goal-Directed Navigation Behaviors

    Authors
    Andrew M. M. Matheson
    Aaron J. Lanz
    Ashley M. Medina
    Al M. Licata
    3 more author(s)...
    Description

    Animals frequently combine odor cues about source identity with wind direction cues about source location to navigate towards a food source. However, where and how these two cues are integrated to support navigation remains unknown. This study described a pathway to the Drosophila fan-shaped body that encodes attractive odor and promotes upwind navigation. Behavioral experiments were performed in a...

    Subject
    Neuroscience
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  • NYU Dataset

    Drosophila Fatty Acid Binding Protein Essential for Light-Dependent Rhodopsin-1 Degradation and Photoreceptor Survival

    Authors
    Huai-Wei Huang
    Hyung Don Ryoo
    Description

    Rhodopsins are light-detecting proteins associated with retinal chromophores. Dysfunctional Rhodopsins cause retinal degeneration in humans and model organisms. However, the mechanisms by which photoreceptors regulate Rhodopsin homeostasis remains unknown. This study performed a photoreceptor-specific gene expression profiling analysis to examine how photoreceptors respond to stress. For their investigation,...

    Subject
    Genomics
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