Animals frequently combine odor cues about source identity with wind direction cues about source location to navigate towards a food source. However, where and how these two cues are integrated to support navigation remains unknown. This study described a pathway to the Drosophila fan-shaped body that encodes attractive odor and promotes upwind navigation. Behavioral experiments were performed in a miniature wind tunnel setup. For calcium imaging, they used older flies to maximize indicator expression, while they used younger flies for electrophysiology to minimize glial ensheathing. This dataset includes behavioral, electrophysiology, immunohistochemistry, and connectomic data. This study revealed that odor and wind cues are processed by separate pathways and integrated within the fan-shaped body to support goal-directed navigation.