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  • NYU Dataset

    Simultaneous recordings of brain activity and pupil size in resting state and during a visual perceptual decision-making task

    Authors
    Ella Podvalny
    Leana E. King
    Biyu J. He
    Description

    To investigate the relationship between two behavioral markers of arousal (pupil size and brain activity) and perceptual decision-making, recordings were simultaneously obtained on pupil size and brain activity using magnetoencephalography (MEG). Data was collected from a total of 24 adult participants during eyes-open rest sessions and a visual perceptual decision-making task. Two 5-minute rest...

    Subject
    Neuroscience
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    Free to All
  • NYU Dataset

    GABA Decrease is Associated With Degraded Neural Specificity in the Visual Cortex of Glaucoma Patients

    Authors
    Ji Won Bang
    Carlos Parra
    Kevin Yu
    Gadi Wollstein
    2 more author(s)...
    Description

    To investigate the GABAergic and glutamatergic systems and neural specificity in the visual cortex of glaucoma patients, the research team recruited 40 patients with glaucoma (14 with early glaucoma and 16 with advanced glaucoma) and 24 age-matched healthy subjects to undergo clinical ophthalmic exams and magnetic resonance imaging (MRI) with fixation tasks. Researchers obtained the following data: Structural...

    Subject
    Anatomy
    Chronic Disease
    Neuroscience
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  • NYU Dataset

    Drosophila Fatty Acid Binding Protein Essential for Light-Dependent Rhodopsin-1 Degradation and Photoreceptor Survival

    Authors
    Huai-Wei Huang
    Hyung Don Ryoo
    Description

    Rhodopsins are light-detecting proteins associated with retinal chromophores. Dysfunctional Rhodopsins cause retinal degeneration in humans and model organisms. However, the mechanisms by which photoreceptors regulate Rhodopsin homeostasis remains unknown. This study performed a photoreceptor-specific gene expression profiling analysis to examine how photoreceptors respond to stress. For their investigation,...

    Subject
    Genomics
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    Free to All
  • NYU Dataset

    Calreticulin Accelerates Corneal Wound Closure and Mitigates Fibrosis

    Authors
    Sarita Mishra
    Miguel A. Manzanares
    Justin Prater
    David Culp
    1 more author(s)...
    Description

    Previous studies demonstrated that topically applied calreticulin (CALR) healed full‐thickness excisional animal wounds by a tissue regenerative process markedly enhancing repair without evoking angiogenesis. This study applied CALR in a rabbit corneal injury model. They accelerated full wound closure by 3 days and delayed healing caused by corticosteroids by 6 days. In addition, healed wounds without...

    Subject
    Anatomy
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    Author Approval Required
  • NYU Dataset

    Impairment of Visual Cortical Plasticity by Amyloid-Beta Species

    Authors
    Christopher M. William
    Matthew A. Stern
    Xuewei Pei
    Lubna Saqran
    3 more author(s)...
    Description

    Alzheimer’s disease (AD) is characterized by accumulation of amyloid-beta (Aβ) in amyloid plaques and transgenic and knock-in mice that express mutant alleles of amyloid precursor protein (APP) have been used to model the effects of Aβ. This study examined visual system plasticity in transgenic mice that express and secrete Aβ throughout the brain in the absence of APP overexpression to explore the...

    Subject
    Neuroscience
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    Application Required
    Author Approval Required
  • NYU Dataset

    Single Cell RNA Sequencing of Human Cornea Organoids Identifies Cell Fates

    Authors
    George Maiti
    Maithe Rocha Monteiro de Barros
    Nan Hu
    Igor Dolgalev
    5 more author(s)...
    Description

    The cornea is the outermost transparent layer of the eye that serves as a protective barrier and studying the cornea can be crucial for understanding human corneal diseases. Although several studies have examined the single-cell transcriptomic composition of the human cornea, its organoids have not been examined similarly. This study explained the transcriptomic cell fate of human cornea organoids...

    Subject
    Anatomy
    Genomics
    Access Rights
    Free to All