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NYU Dataset
Simultaneous recordings of brain activity and pupil size in resting state and during a visual perceptual decision-making task
- Authors
- Ella PodvalnyLeana E. KingBiyu J. He
- Description
To investigate the relationship between two behavioral markers of arousal (pupil size and brain activity) and perceptual decision-making, recordings were simultaneously obtained on pupil size and brain activity using magnetoencephalography (MEG). Data was collected from a total of 24 adult participants during eyes-open rest sessions and a visual perceptual decision-making task. Two 5-minute rest...
- Subject
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Neuroscience
- Access Rights
- Free to All
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NYU Dataset
GABA Decrease is Associated With Degraded Neural Specificity in the Visual Cortex of Glaucoma Patients
- Authors
- Ji Won BangCarlos ParraKevin YuGadi Wollstein2 more author(s)...
- Description
To investigate the GABAergic and glutamatergic systems and neural specificity in the visual cortex of glaucoma patients, the research team recruited 40 patients with glaucoma (14 with early glaucoma and 16 with advanced glaucoma) and 24 age-matched healthy subjects to undergo clinical ophthalmic exams and magnetic resonance imaging (MRI) with fixation tasks. Researchers obtained the following data: Structural...
- Subject
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AnatomyChronic DiseaseNeuroscience
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- Free to All
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NYU Dataset
Drosophila Fatty Acid Binding Protein Essential for Light-Dependent Rhodopsin-1 Degradation and Photoreceptor Survival
- Authors
- Huai-Wei HuangHyung Don Ryoo
- Description
Rhodopsins are light-detecting proteins associated with retinal chromophores. Dysfunctional Rhodopsins cause retinal degeneration in humans and model organisms. However, the mechanisms by which photoreceptors regulate Rhodopsin homeostasis remains unknown. This study performed a photoreceptor-specific gene expression profiling analysis to examine how photoreceptors respond to stress. For their investigation,...
- Subject
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Genomics
- Access Rights
- Free to All
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NYU Dataset
Calreticulin Accelerates Corneal Wound Closure and Mitigates Fibrosis
- Authors
- Sarita MishraMiguel A. ManzanaresJustin PraterDavid Culp1 more author(s)...
- Description
Previous studies demonstrated that topically applied calreticulin (CALR) healed full‐thickness excisional animal wounds by a tissue regenerative process markedly enhancing repair without evoking angiogenesis. This study applied CALR in a rabbit corneal injury model. They accelerated full wound closure by 3 days and delayed healing caused by corticosteroids by 6 days. In addition, healed wounds without...
- Subject
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Anatomy
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- Application RequiredAuthor Approval Required
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NYU Dataset
Impairment of Visual Cortical Plasticity by Amyloid-Beta Species
- Authors
- Christopher M. WilliamMatthew A. SternXuewei PeiLubna Saqran3 more author(s)...
- Description
Alzheimer’s disease (AD) is characterized by accumulation of amyloid-beta (Aβ) in amyloid plaques and transgenic and knock-in mice that express mutant alleles of amyloid precursor protein (APP) have been used to model the effects of Aβ. This study examined visual system plasticity in transgenic mice that express and secrete Aβ throughout the brain in the absence of APP overexpression to explore the...
- Subject
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Neuroscience
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- Application RequiredAuthor Approval Required
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NYU Dataset
Single Cell RNA Sequencing of Human Cornea Organoids Identifies Cell Fates
- Authors
- George MaitiMaithe Rocha Monteiro de BarrosNan HuIgor Dolgalev5 more author(s)...
- Description
The cornea is the outermost transparent layer of the eye that serves as a protective barrier and studying the cornea can be crucial for understanding human corneal diseases. Although several studies have examined the single-cell transcriptomic composition of the human cornea, its organoids have not been examined similarly. This study explained the transcriptomic cell fate of human cornea organoids...
- Subject
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AnatomyGenomics
- Access Rights
- Free to All