NYU Dataset

Calreticulin Accelerates Corneal Wound Closure and Mitigates Fibrosis

UID: 10692
* Corresponding Author
Description

Previous studies demonstrated that topically applied calreticulin (CALR) healed full‐thickness excisional animal wounds by a tissue regenerative process markedly enhancing repair without evoking angiogenesis. This study applied CALR in a rabbit corneal injury model. They accelerated full wound closure by 3 days and delayed healing caused by corticosteroids by 6 days. In addition, healed wounds without vascularization or fibrosis. For the study, they used New Zealand rabbits, human corneal epithelial cells, and corneal stromal cells. This dataset includes corneal evaluation, histopathology, immunohistochemistry, cell proliferation, and cell migration data. The results indicate that CALR has the potential to accelerate corneal healing from various injuries.

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Associated Publications
Data Type
Equipment Used
Agilent BioTek Synergy Neo2
Keeler Vantage Plus
Kowa SL‐17
Leica Optical Coherence Tomography
Olympus CK2
Software Used
GraphPad Prism v9.0
ImageJ
OMERO
Grant Support
Tissue Regeneration Sciences/Tissue Regeneration Sciences