NYU Dataset
GABA Decrease is Associated With Degraded Neural Specificity in the Visual Cortex of Glaucoma Patients
Part of: NeuroImaging and Visual Science Laboratory |
UID: 10631
- Description
- To investigate the GABAergic and glutamatergic systems and neural specificity in the visual cortex of glaucoma patients, the research team recruited 40 patients with glaucoma (14 with early glaucoma and 16 with advanced glaucoma) and 24 age-matched healthy subjects to undergo clinical ophthalmic exams and magnetic resonance imaging (MRI) with fixation tasks. Researchers obtained the following data:
- Structural and functional images of the whole brain
- Neurochemical profiles of the visual cortex
- Measures of GABA concentration via MEshcher-GArwood- Point RESolved Spectroscopy (MEGA-PRESS)
- Measures of glutamate concentration via Point RESolved Spectroscopy (PRESS)
- Clinical ophthalmic measures:
- Peripapillary retinal nerve fiber layer (pRNFL) thickness
- Macular ganglion cell-inner plexiform layer (mGCIPL) thickness
- Optic nerve head cup-to-disc (C/D) ratio
- Neuroretinal rim (NRR) area from optical coherence tomography (OCT)
- Visual field mean deviation (MD) from Humphrey standard automated perimetry
- Timeframe
- 2018 - 2022
- Geographic Coverage
-
New York (State) - New York City
Homo sapiens
Subject Domain
Population Age
Keywords
Adult (19 years - 64 years)
Senior (65 years - 79 years)
Aged (80 years and over)
Access
- Restrictions
-
Free to All
- Instructions
- Data (excluding raw imaging data) and statistical code for statistical parametric mapping can be accessed through the OpenScienceFramework (OSF) repository.
Observational
Humphrey Swedish Interactive Thresholding Algorithm (SITA) 24-2 Standard
- Grant Support
-
G2016030/BrightFocus FoundationG2019103/BrightFocus FoundationG2021001F/BrightFocus FoundationUnrestricted Grant/Research to Prevent Blindness
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