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  • NYU Dataset

    Two-Photon Imaging Indicates Dopamine Modulates the Size of Spiny Projection Neurons

    Authors
    Marta Maltese
    Jeffrey R. March
    Alexander G. Bashaw
    Nicolas X. Tritsch
    Description

    Dopamine is a critical modulator of brain circuits that control voluntary movements. However, its influence on the activity of target neurons in vivo remains limited. In this study, two-photon microscopy was used to monitor the activity of direct and indirect-pathway spiny projection neurons (SPNs) simultaneously in the striatum of behaving mice. The striatum mainly consists of two large populations...

    Subject
    Neuroscience
    Surgery
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    Free to All
  • NYU Dataset

    Inhibitory Co-Transmission From Midbrain Dopamine Neurons Relies on Presynaptic GABA Uptake

    Authors
    Riccardo Melani
    Nicolas X. Tritsch
    Description

    Dopamine releasing neurons in the substantia nigra pars compacta inhibit target cells in the striatum through postsynaptic activation of γ-aminobutyric acid (GABA) receptors. However, the molecular mechanisms responsible for GABAergic signaling remains unknown. This study found that inhibitory co-transmission from midbrain dopaminergic neurons does not depend on cell-autonomous GABA synthesis, but...

    Subject
    Neuroscience
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  • NYU Dataset

    Dopamine Neurons in Caenorhabditis elegans Governs Food Response Behaviors

    Authors
    Alice Fok
    Benjamin Brissette
    Tim Hallacy
    Hassan Ahamed
    3 more author(s)...
    Description

    Caenorhabditis elegans (C. elegans) uses specialized mechanosensory neurons to detect food. These neurons release dopamine to suppress foraging and promote dwelling. This study identified genes highly expressed in dopaminergic food-sensing neurons and screened for defects in the food-triggered slowing behavior mediated by these neurons. They found a K2P-family potassium channel gene TWK-2 that mutates...

    Subject
    Genomics
    Neuroscience
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    Free to All
  • NYU Dataset

    Dopamine Responses and Functions in Nucleus Accumbens Core During Social Behaviors

    Authors
    Bing Dai
    Fangmiao Sun
    Xiaoyu Tong
    Yizhuo Ding
    4 more author(s)...
    Description

    Social behaviors are among the most notable motivated behaviors that are driven by rewarding goals. However, how dopamine (DA), a reward signal, releases during social behaviors has been unclear. This study used a genetically encoded DA sensor, GRABDA2m, to record DA activity in the nucleus accumbens (NAc) core during various social behaviors in male and female mice. They performed optical recording...

    Subject
    Neuroscience
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