NYU Dataset
Experience-Dependent Dopamine Modulation of Male Aggression
Part of: Lin Lab |
Part of: Oxytocin U19 BRAIN Initiative |
UID: 10743
- Description
Aggression is an innate social behaviour that is essential for defending territory, competing for resources, and securing mates. This study demonstrated that dopaminergic cells in the ventral tegmental area (VTA) can bidirectionally modulate aggression in male mice in an experience-dependent manner. To investigate the role of experience-dependent dopamine modulation on aggression, they tested the effect of VTADAT inhibition in novice and expert aggressors. This dataset contains behavioral annotations, tracking, fiber photometry, slice electrophysiology, and raw representative histology images. These results indicate a prominent role of dopamine in the rise of aggression in adult male mice.
C57BL/6N mice
BALB/c mice
Esr1-2A-Cre mice
Drd2-Cre mice
Associated Publications
Data Type
Equipment Used
Software Used
Access
- Restrictions
-
Free to All
- Instructions
- Behavioral annotations, tracking, fiber photometry, slice electrophysiology and raw representative histology images as well as MATLAB codes used in this study can be downloaded from Zenodo. Illustrations of the coronal brain sections are based on images from the Allen Brain Reference Atlas and the source data are provided with this paper on Nature.
Thorlabs CFLC230
- Grant Support
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Vulnerable Brain Project/NYU Langone Health
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