NYU Health Sciences Library NYU Data Catalog
NYU Health Sciences Library NYU Data Catalog
NYU Health Sciences Library Data Catalog

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Results Found: 5

  • New York City Health and Nutrition Examination Study

    Alternate Title(s)
    NYC HANES
    Authors
    Lorna E. Thorpe
    Description

    The NYC Health and Nutritional Examination Survey (NYC HANES), modeled on the National Health and Nutrition Examination Survey (NHANES), is a population-based, cross-sectional study with data collected from physical examinations, clinical and laboratory tests, as well as face-to-face interviews and audio computer-assisted self-interviews (ACASI). It was first conducted in 2004 by the NYC Department...

    Subject
    Chronic Disease
    Health Status
    Mental Health
    Population Characteristics
    Risk Factors
    Access Rights
    Free to All
    Local Expert
    Bonnie Kerker
    Rania Kanchi
  • NYU Dataset

    MicroRNA-33 Silencing Reprograms the Immune Cell Landscape in Atherosclerotic Plaques

    Authors
    Milessa Silva Afonso
    Monika Sharma
    P. Martin Schlegel
    Coen van Solingen
    11 more author(s)...
    Description

    MicroRNA-33 (miR-33) targeted inhibition increases plasma HDL cholesterol and promotes atherosclerosis regression by enhancing reverse cholesterol transport and dampening plaque inflammation. This study showed how miR-33 inhibition alters the dynamic balance and transcriptional landscape of immune cells in atherosclerotic plaques. They used single cell RNA sequencing of aortic CD45+ cells, combined...

    Subject
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    DIAPH1 Mediates Progression of Atherosclerosis and Regulates Hepatic Lipid Metabolism in Mice

    Authors
    Laura Senatus
    Lander Egana-Gorrono
    Raquel Lopez-Diez
    Sonia Bergaya
    17 more author(s)...
    Description

    Previous study indicated that the receptor for advanced glycation end products (RAGE) in the progression and regression of atherosclerosis. Therefore, this study examined if Diaphanous 1 (DIAPH1) binds to the RAGE cytoplasmic domain and contributes to progression of atherosclerosis. They intercrossed atherosclerosis prone Ldlr−/− mice with mice devoid of Diaph1 and fed them Western diet for 16 weeks....

    Subject
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    IRG1–Itaconate Axis Protects From Cholesterol-Induced Inflammation and Atherosclerosis

    Authors
    Yannick Cyr
    Fazli K. Bozal
    Jose Gabriel Barcia Duran
    Alexandra A. C. Newman
    17 more author(s)...
    Description

    Therapeutic approaches to reverse atherosclerotic inflammation are needed to address the rising global burden of cardiovascular disease (CVD). This study investigated therapeutic potential of the enzyme immune responsive gene 1 (IRG1) and its immunomodulatory product, itaconate for atherosclerosis in humans and mice. To investigate the expression of IRG1 in human atherosclerosis, single-cell RNA sequencing...

    Subject
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    Human Hepatoma Huh-7 Cell Culture Models Deficient in Apolipoprotein B Secretion

    Authors
    Swati Valmiki
    Sara Rosario
    Ashley Mooring
    Chandana Prakashmurthy
    7 more author(s)...
    Description

    Apolipoprotein B (apoB) is an essential structural protein for the assembly and secretion of triglyceride-rich lipoproteins. Inhibition of apoB and microsomal triglyceride transfer protein (MTP) decreases plasma lipid levels but at a risk of lipid accumulation in tissues. To understand the global consequences of APOB gene deficiency, a human hepatoma (Huh-7) cell culture model system deficient in apoB...

    Subject
    Genomics
    Access Rights
    Free to All