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  • NYU Dataset

    Biomimetic Extracellular Matrix Nanofibers Electrospun with Calreticulin Promote Synergistic Activity for Tissue Regeneration

    Authors
    Mary E. Stack
    Sarita Mishra
    Matangi Parimala Chelvi Ratnamani
    Haoyu Wang
    2 more author(s)...
    Description

    Previous studies showed the potential of calreticulin (CRT) protein in enhancing the rate and quality of wound healing in excisional animal wound models. This study determined if polycaprolactone (PCL)/type 1 collagen (Col1) nanofibers (NFs) could be used as an effective carrier for CRT while at the same time introducing further wound healing capability through the synergy of biological and physicochemical...

    Subject
    Anatomy
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    Author Approval Required
  • NYU Dataset

    Calreticulin Accelerates Corneal Wound Closure and Mitigates Fibrosis

    Authors
    Sarita Mishra
    Miguel A. Manzanares
    Justin Prater
    David Culp
    1 more author(s)...
    Description

    Previous studies demonstrated that topically applied calreticulin (CALR) healed full‐thickness excisional animal wounds by a tissue regenerative process markedly enhancing repair without evoking angiogenesis. This study applied CALR in a rabbit corneal injury model. They accelerated full wound closure by 3 days and delayed healing caused by corticosteroids by 6 days. In addition, healed wounds without...

    Subject
    Anatomy
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    Application Required
    Author Approval Required
  • NYU Dataset

    MPC309 Modulates Androgen Receptor Transcriptional Activity to Inhibit Therapy-Resistant Prostate Cancer

    Authors
    Justine Habault
    Jeffrey A. Schneider
    Susan Ha
    Rachel Ruoff
    14 more author(s)...
    Description

    Prostate cancer cells depend on the androgen receptor (AR) for survival and proliferation. This study examined the antitumor effects of compound MPC309, a trivalent display of ethisterone conjugated to a peptoid oligomer backbone that binds to the AR with nanomolar affinity. First, a structure-activity relationship study was performed to improve multivalent peptoid conjugate potency. Then, the impact...

    Subject
    Cancer
    Genomics
    Access Rights
    Free to All