Microsporidia are obligate intracellular pathogens that infect a wide range of invertebrate and vertebrate hosts, including humans. In humans, microsporidia most often infect the gastrointestinal tract and cause diarrheal diseases, but in immunocompromised patients, infections can be fatal. Previous knowledge of microsporidian intracellular development was based on 2D transmission electron microscopy...

The Buzsáki Lab has shared designs for a 3D-printed metal microdrive and head cap system for freely-moving rodents and sample electrophysiological recordings. The modular design allows for recovery and reuse of silicon probes in multiple experiments with mice and Long-Evans rats. The .step files for the metal microdrive are optimized for stainless steel 316L in 20 micrometer resolution and aluminum...

Fighting is a major means to compete for limited resources in the wild. After the fight ends, the loser continuously avoids close interaction with the winner and readily flees when confronted. The neural mechanisms that underlie the rapid and long-lasting behavioral changes induced by defeat remains unclear. This study identified oxytocin neurons in the retrochiasmatic supraoptic nucleus and oxytocin-receptor-expressing...

Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 ACUTE (ACTIV4A) is a randomized, open label, adaptive platform trial that compares the effectiveness of several antithrombotic strategies for the prevention of adverse outcomes in COVID-19 positive inpatients. Investigators assessed outcomes such as the number of days that a patient is alive and free of organ support through the first 21...

Matthay et al integrated multiple data sources to investigate the association between local policies in California on cannabis outlet distribution, particularly in vulnerable neighborhoods. For 241 localities within 12 counties in California, the investigators identified seven policies pertaining to the density or location of recreational cannabis outlets, geocoded outlets using web-scraped data from...

The Social Determinants of Health (SDOH) Database was created by the Agency for Healthcare Research and Quality (AHRQ) with funding from the Patient Centered Outcomes Research (PCOR) Trust Fund to enable research with linkable SDOH-focused data derived from multiple sources and across multiple domains. Since the data is compiled from multiple sources, users are advised to consult the associated documentation...

This dataset consists of AI prompts used to improve the content and quality of medical documentation in a case study at NYU Langone Health. Both prompts were used with institutional instance of GPT-4. The first prompt checks for completeness of a clinical note, ensuring that comments from the patients, an all-encompassing description of the patient, a description of the appropriate exam, and an update...

The AMA Physician Masterfile includes education, training and professional certification information on virtually all Doctors of Medicine (MD) and Doctors of Osteopathic Medicine (DO) in the United States, Puerto Rico, Virgin Islands, and certain Pacific Islands. It includes current and historical data for more than 1.4 million physicians, residents, and medical students in the United States. This...

This study identified biological targets in major depressive disorder (MDD). Acetyl-l-carnitine (LAC), which is critical for hippocampal function and several behavioral domains, has rapid and enduring antidepressant like effects in LAC deficient rodents. As a result, this study examined LAC levels in humans. Following an initial phone screen, potential participants were evaluated in person to determine...

Action to Control Cardiovascular Risk in Diabetes (ACCORD) was a large clinical trial examining methods of lowering the rate of cardiovascular disease in adults with type two diabetes. The study was composed of three main clinical trials: an intensive lowering of blood sugar levels (Glycemia Trial), intensive lowering of blood pressure (Blood Pressure Trial), and treatment of multiple blood lipids...