Oxytocin Induces Embryonic Diapause in Mice
- Description
This study demonstrate that oxytocin induces diapause, a temporary developmental delay, in pre-implantation mouse embryos to help ensure their survival. To assess whether oxytocin receptor (OXTR) signaling might influence this gestational delay, heterozygous (OXTR+/−) dams were bred, which retain sufficient OXTR function for apparently normal parturition and nursing. After the second breeding, these animals also experienced a prolonged gestational delay. The dataset includes source data and statistical analysis for figures, which contains data on OXTRs help pups survive lactationally-induced diapause, patterned optogenetic oxytocin neuron activation induces diapause, mouse blastocysts express oxytocin receptors, mouse blastocyst OXTR signaling induces diapause-like state in vitro, and OXTR signaling helps embryos survive diapause.
Access
- Restrictions
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Free to All
- Instructions
- All data needed to evaluate the conclusions in the paper are present in the paper on PubMed Central (PMC) under Supplementary Materials.
- Grant Support
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Edward Mallinckrodt Jr. Foundation/Edward Mallinckrodt Jr. FoundationBarnard College Summer Research Institute/Golden Family Foundation Endowment Fund