Isolation of Clostridia from the Gut Microbiome of Helminth-Colonized Humans
- Description
Helminth colonization has been associated with altered composition of the gut microbiota, such as increases in Clostridia. However, it is unclear if specific bacterial species display differential effects on helminth reproduction. This study isolated and sequenced the genome of 13 Clostridia from the Orang Asli, an indigenous population in Malaysia with a high prevalence of helminth infections. Metagenomic analysis of 650 fecal samples from urban and rural Malaysians confirm the prevalence of species corresponding to these isolates.
This dataset includes sequencing and assembled whole genome sequencing data as well as supplementary data tied to the publication. The supplementary data contains several tables, which includes data on sample characteristics of the Orang Asli cohort from Pangsun village, GTDB-Tk taxonomy, metabolic pathways, gene orthologs, 47 closest relatives, and peptostreptococcaceae. The data provides genomic characterization of bacteria isolated from helminth-colonized Orang Asli villagers.
Access
- Restrictions
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Free to All
- Instructions
- Raw sequences and assembled whole genome sequences reported in this study are available under NCBI BioProject.
- Grant Support
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HHMI Faculty Scholars/Howard Hughes Medical InstituteCrohn’s & Colitis Foundation/Crohn’s & Colitis FoundationKenneth Rainin Foundation/Kenneth Rainin FoundationJudith & Stewart Colton Center for Autoimmunity/NYU Langone HealthAntimicrobial-Resistant Pathogens Program/NYU Langone HealthPacBio Local SMRT Grant/PacBioDivision of Intramural Research/National Institute of Allergy and Infectious Diseases