NYU Dataset
An eIF3d-Dependent Switch Regulates Human Cytomegalovirus Replication
Part of: Mohr Lab |
UID: 10602
- Description
Gene expression rapidly responds to physiological stress like virus infection in part via the control of mRNA translation. However, how translation of virus and host mRNAs are regulated during infection stress remains unknown. This study showed that protein synthesis in human cytomegalovirus (HCMV)-infected cells unexpectedly becomes progressively reliant upon eIF3d, which is a mRNA cap-binding protein that is required for specialized translation initiation. This dataset contains RNA sequencing data. The data suggests that the overall abundance of eIF3 protein subunits, including the cap-interacting subunit eIF3d, increases in response to HCMV infection.
Vero cells
Fibroblasts
ARPE-19 cells
Associated Publications
Data Type
Equipment Used
Software Used
Access
- Restrictions
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Free to All
- Instructions
- All sequencing datasets generated during this study have been deposited at the European Nucleotide Archive (ENA).
- Grant Support
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