NYU Dataset

An eIF3d-Dependent Switch Regulates Human Cytomegalovirus Replication

Part of: Mohr Lab |
UID: 10602
* Corresponding Author
Description

Gene expression rapidly responds to physiological stress like virus infection in part via the control of mRNA translation. However, how translation of virus and host mRNAs are regulated during infection stress remains unknown. This study showed that protein synthesis in human cytomegalovirus (HCMV)-infected cells unexpectedly becomes progressively reliant upon eIF3d, which is a mRNA cap-binding protein that is required for specialized translation initiation. This dataset contains RNA sequencing data. The data suggests that the overall abundance of eIF3 protein subunits, including the cap-interacting subunit eIF3d, increases in response to HCMV infection.

Subject of Study
Subject Domain
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Access

Restrictions
Free to All
Instructions
All sequencing datasets generated during this study have been deposited at the European Nucleotide Archive (ENA).
Access via ENA


Accession #: PRJEB45749

Associated Publications
Data Type
Equipment Used
Bio-Rad C1000 Touch Thermal Cycler
CellInsight CX7 LZR
iBright FL1000 Imaging System
Illumina NovaSeq 6000
Zeiss Axiovert 200
Software Used
BBTools
bedtools
biomaRt
ComBat-seq
GENCODE v37
ggplot2
GraphPad Prism
HCS Studio
Kallisto
limma
Microsoft Excel
Reactome
RIVET
SAMtools
STAR
TrimGalore
Grant Support