Brain Insulin Resistance in Subjects with Major Depressive Disorder
- Description
Previous studies in rodent showed impaired brain insulin signaling with resultant insulin resistance (IR) modulates synaptic plasticity and the corresponding behavioral functions. This study investigated whether brain enriched exosomes and brain IR differ between subjects with major depressive disorder (MDD) and respective controls. They also examined potential sex differences in circulating brain enriched exosomes as well as a link between brain insulin signaling and severity of depressive symptoms. Following an initial phone screen, potential participants were evaluated in person in order to determine study eligibility. The age range of participants were between 20 and 70 years. Clinical assessment consisted of a physical examination, which included measures of height, weight, and body mass index (BMI). They also collected data on current medication use, history of failed antidepressant trials, and demographic information.
Access
- Restrictions
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Application RequiredAuthor Approval Required
- Instructions
- Please complete the Data Request Form to request access to this dataset. The information included in the form will be sent to the Corresponding Author who will evaluate your request for their data. The Corresponding Author may ask you to provide additional information if necessary.
- Grant Support
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Robertson Therapeutic Development Found/Robertson Therapeutic Development FoundHearst Foundation/Hearst FoundationHope for Depression Research Foundation/Hope for Depression Research Foundation