The Upstate New York Infant Development Screening (Upstate KIDS) Study is a collaboration between the New York State Department of Health, University at Albany, and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The study includes information from over 5,034 mothers and their 6,171 children in New York State, excluding New York City, who were recruited between 2008 and 2010 through registry sampling. The objectives of the study were to examine associations between parental health conditions and exposures (e.g., infertility treatments, environmental exposures) and the physical, motor, and social development of their children through 3 years of age. Participating mothers completed questionnaires for their children at their 4, 8, 12, 18, 24, 30, and 36 month old milestones. At 8 months, additional parental consent was obtained to request retrieval and analysis of dried blood spots collected at birth through the Newborn Screening Program. These samples were analyzed for inflammatory and environmental chemical biomarkers. 600 infants received additional neurodevelopmental evaluations at 36 to 48 months.

The Upstate KIDS Follow-Up Study follows approximately 3,200 children from the original cohort to examine cardio-metabolic risks that may be associated with exposure to infertility treatments. Data collection is ongoing through annual parent questionnaires, clinical exams, and saliva collection programs.