Nurses' Health Studies

Alternate Titles(s): NHS, NHS I, NHS II, NHS3, GUTS, Growing Up Today Study, GUTS
UID: 10045

The Nurses' Health Studies (NHS) are long-running, questionnaire-based studies on women's health. The study was initiated in 1976 with the NHS cohort. The initial studies focus on cancer, cardiovascular disease and risk factors for chronic health issues in women. The latest cohort, NH3, has been expanded to include both male and female registered nurses and nursing students. Survey and biospecimen data may be requested by interested researchers.

There a number of study cohorts:

  • NHS: Beginning in 1976, this study included 121,700 female registered nurses in the US who were aged 30-55 years old at baseline.
  • NHS II: Beginning in 1989, this study included 116,429 female registered nurses in the US who were aged 25-42 years old at baseline.
  • Growing up Today Study (GUTS): Beginning in 1996, this study included 27,706 male and female offspring of NHS II participants who were aged 9-14 at baseline.
  • GUTS2: Beginning in 2004, the second phase of GUTS included 10,923 children of NHS II participants who were aged 10-17 at baseline.
  • NHS3: Beginning in 2010, this study includes over 40,000 male and female nurses and nursing students in the United States and Canada who are at least 19 years old at baseline. Recruitment is ongoing.

1976 - Present
Geographic Coverage
United States
Subject of Study
Subject Domain
Population Age
Child (2 years - 12 years)
Adolescent (13 years - 18 years)
Adult (19 years - 64 years)
Senior (65 years - 79 years)
Aged (80 years and over)


Fee Required
Application Required

Prospective researchers must complete the External Collaboration Request Form and explain their research hypothesis, significance, proposed use of data, cohort data variables needed for analysis, reasons for using NHS data and discussion of ethical implications. Researchers must provide funding for their studies, including funding for an NHS staff member as co-investigator.

Application instructions for accessing biospecimens may be found on the BWH/Harvard Cohorts Biorepository website.

Access via Nurses' Health Studies

Application instructions for questionnaire and biospecimen data

Access via Growing Up Today Study

Application instructions for questionnaire and biospecimen data

Data Type
Study Type
Dataset Format(s)
PubMed Search
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