NYU Data Catalog

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  • NYU Dataset

    Novel pH Modulation of Lysosomes Through β2-Adrenergic Regulation of ClC-7 in Alzheimer’s Disease

    Authors
    Ju-Hyun Lee
    Devin M. Wolfe
    Sandipkumar Darji
    Mary Kate McBrayer
    5 more author(s)...
    Description

    Lysosomal dysfunction plays a key role in the pathogenesis of Alzheimer’s disease (AD) and Parkinson’s disease (PD). In early onset of AD, there is loss of Presenilin-1 (PSEN1) function. The loss of PSEN1 function impedes ER to lysosome delivery of chloride channel-7 (ClC-7). In murine blastocysts with different PSEN1 genotypes, isoproterenol and related β2-adrenergic agonists was used to reverse lysosomal...

    Subject
    Genomics
    Neuroscience
    Access Rights
    Free to All
  • NYU Dataset

    Hypothalamic Melanin-Concentrating Hormone Regulates Hippocampus-Dorsolateral Septum Activity

    Authors
    Jing-Jing Liu
    Richard W. Tsien
    Zhiping P. Pang
    Description

    Hypothalamic melanin-concentrating hormone (MCH) polypeptide contributes to regulating energy homeostasis, sleep, and memory. However, the mechanistic bases of its effects are still unclear. This study found that the physiological mechanism underlying the functional role of MCH signaling in projections to the dorsolateral septum (dLS), which is a region involved in routing hippocampal firing rhythms...

    Subject
    Neuroscience
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  • NYU Dataset

    MicroRNA-33 Silencing Reprograms the Immune Cell Landscape in Atherosclerotic Plaques

    Authors
    Milessa Silva Afonso
    Monika Sharma
    Martin Schlegel
    Coen van Solingen
    11 more author(s)...
    Description

    MicroRNA-33 (miR-33) targeted inhibition increases plasma HDL cholesterol and promotes atherosclerosis regression by enhancing reverse cholesterol transport and dampening plaque inflammation. This study showed how miR-33 inhibition alters the dynamic balance and transcriptional landscape of immune cells in atherosclerotic plaques. They used single cell RNA sequencing of aortic CD45+ cells, combined...

    Subject
    Genomics
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  • NYU Dataset

    Energy Coupling and Stoichiometry of Zn2+/H+ Antiport by YiiP

    Authors
    Adel Hussein
    Shujie Fan
    Maria Lopez-Redondo
    Ian Kenney
    3 more author(s)...
    Description

    Previous studies of YiiP, bacterial Zn2+/H+ antiporter, have shown a homodimeric architecture and the presence of three distinct Zn2+ binding sites. YiiP is a representative of the cation diffusion facilitator superfamily, which are responsible for homeostasis of transition metal ions. This study used cryo-electron microscopy, microscale thermophoresis, and molecular dynamics simulations to address...

    Subject
    Cell Physiology
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