NYU Dataset
Energy Coupling and Stoichiometry of Zn2+/H+ Antiport by YiiP
Part of: Stokes Lab |
UID: 10655
- Description
Previous studies of YiiP, bacterial Zn2+/H+ antiporter, have shown a homodimeric architecture and the presence of three distinct Zn2+ binding sites. YiiP is a representative of the cation diffusion facilitator superfamily, which are responsible for homeostasis of transition metal ions. This study used cryo-electron microscopy, microscale thermophoresis, and molecular dynamics simulations to address the structural and functional roles of individual sites as well as the interplay between Zn2+ binding and protonation. The dataset includes coordinates for the atomic models and the corresponding density maps, and raw simulation data. In addition, the publication has supplementary data that contains source data for figures.
BL21(DE3)
Associated Publications
Data Type
Equipment Used
Software Used
Access
- Restrictions
-
Free to All
- Instructions
- Coordinates for the atomic models have been deposited in the Protein Data Bank (PDB). The corresponding density maps have been deposited in the Electron Microscopy Data Bank (EMDB). The raw simulation data are stored in Open Science Framework (OSF) and all code are stored in GitHub repository.
- Grant Support
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1548562/NSFBiological and Environmental Research/Department of Energy
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