NYU Data Catalog

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  • NYU Dataset

    Transposon Insertion Profiling by Sequencing (TIPseq) Utilized for LINE-1 Mapping in Single Cells

    Authors
    Wilson McKerrow
    Zuojian Tang
    Jared P. Steranka
    Lindsay M. Payer
    5 more author(s)...
    Description

    This dataset was compiled to determine a genome-wide long interspersed element-1 (LINE-1) insertion site mapping method for bulk DNA. This study has shown that transposon insertion profiling by sequencing (TIPseq) is a method that can be used for LINE-1 mapping in single cells. Live GM12878 lymphoblastoid cells were used for this study. The dataset contains sequencing data as well as supplementary...

    Subject
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    Condensation of ORF1p is Critical for LINE-1 Retrotransposition

    Authors
    Srinjoy Sil
    Sarah Keegan
    Farida Ettefa
    Lance T. Denes
    2 more author(s)...
    Description

    Long interspersed element-1 (LINE-1) is an autonomously active retrotransposon in the human genome. The LINE-1 mRNA encodes two proteins, ORF1p and ORF2p, which are essential for retrotransposition. This study showed that electrostatic interactions and trimer conformational dynamics together tune the properties of ORF1p assemblies to allow for efficient LINE-1 ribonucleoprotein complex formation in...

    Subject
    Cell Physiology
    Access Rights
    Free to All