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  • NYU Dataset

    Correlation Between Autoimmunity to Phosphatidylserine and Anemia in African Trypanosome Infections

    Authors
    Juan Rivera-Correa
    Joseph Verdi
    Julian Sherman
    Jeremy M. Sternberg
    2 more author(s)...
    Description

    Anemia is a common complication in many infectious diseases, including protozoan parasitic infections. Trypanosomes are eukaryotic parasites and most relevant human trypanosome pathogens are Trypanosoma brucei and Trypanosoma cruzi. Autoimmunity during Trypanosoma brucei infection is indicated to have a role during anemia, but anemia caused by trypanosome infection is poorly understood. In mouse models...

    Subject
    Infectious Disease
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    Free to All
  • NYU Dataset

    Isolation of Clostridia from the Gut Microbiome of Helminth-Colonized Humans

    Authors
    Shushan Sargsian
    Ze Chen
    Soo Ching Lee
    Amicha Robertson
    14 more author(s)...
    Description

    Helminth colonization has been associated with altered composition of the gut microbiota, such as increases in Clostridia. However, it is unclear if specific bacterial species display differential effects on helminth reproduction. This study isolated and sequenced the genome of 13 Clostridia from the Orang Asli, an indigenous population in Malaysia with a high prevalence of helminth infections. Metagenomic...

    Subject
    Genomics
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  • NYU Dataset

    3D Reconstructions of Parasite Development and the Intracellular Niche of Encephalitozoon intestinalis

    Authors
    Noelle V. Antao
    Cherry Lam
    Ari Davydov
    Margot Riggi
    6 more author(s)...
    Description

    Microsporidia are obligate intracellular pathogens that infect a wide range of invertebrate and vertebrate hosts, including humans. In humans, microsporidia most often infect the gastrointestinal tract and cause diarrheal diseases, but in immunocompromised patients, infections can be fatal. Previous knowledge of microsporidian intracellular development was based on 2D transmission electron microscopy...

    Subject
    Infectious Disease
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  • NYU Dataset

    Energetics of the Microsporidian Polar Tube Invasion Machinery

    Authors
    Ray Chang
    Ari Davydov
    Pattana Jaroenlak
    Breane Budaitis
    3 more author(s)...
    Description

    Microsporidia are obligate intracellular parasites that use an unusual invasion organelle called the polar tube (PT), which is ejected from a dormant spore at ultra-fast speeds, to infect host cells. This study used serial block-face scanning electron microscopy (SBF-SEM) to capture 3-dimensional snapshots of Anncaliia algerae spores in different states of the PT ejection process. They proposed a theoretical...

    Subject
    Infectious Disease
    Access Rights
    Free to All