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Results Found: 5

  • Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial Datasets

    Alternate Title(s)
    PLCO
    Description

    The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial was a large randomized controlled trial that assessed whether certain screening practices decreased deaths from prostate, lung, colorectal and ovarian cancer. Approximately 155,000 men and women aged 55 to 74 years old were enrolled from 10 screening centers across the United States between November 1993 and July 2001. Participants...

    Subject
    Cancer
    Chronic Disease
    Health Care System
    Access Rights
    Application Required
    Local Expert
    Richard B. Hayes
  • NYU Dataset

    NFS1 Undergoes Positive Selection in Lung Tumors and Protects Cells from Ferroptosis

    Authors
    Samantha W. Alvarez
    Vladislav O. Sviderskiy
    Erdem M. Terzi
    Thales Papagiannakopoulos
    5 more author(s)...
    Description

    This study performed loss-of-function screens in a transformed breast cell line using a metabolism-restricted short hairpin RNA (shRNA) library to understand differences in metabolic pathway requirements between in vitro model systems and in vivo tumors. They found that cancer cells depend on high levels of the iron–sulfur cluster biosynthetic enzyme NFS1. This dataset includes supplementary data tied...

    Subject
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    Inhibition of SHP2 and CXCR1/2 Promotes Antitumor T-cell Response in Non-Small Cell Lung Cancer

    Authors
    Kwan Ho Tang
    Shuai Li
    Alireza Khodadadi-Jamayran
    Jayu Jen
    14 more author(s)...
    Description

    SHP2 plays critical roles in normal cell signaling and SHP2 inhibitors alone and in various combinations are being tested in multiple tumors with overactivation of the RAS/ERK pathway. This study showed that inhibiting the SHP2/RAS/ERK pathway triggers upregulation of CXCR2 ligands. In this study, C57BL/6J mice were used as the orthotopic allograft lung cancer model. They injected KP cells into the...

    Subject
    Cancer
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    KEAP1 Mutation in Lung Adenocarcinoma Promotes Immune Evasion and Immunotherapy Resistance

    Authors
    Anastasia-Maria Zavitsanou
    Ray Pillai
    Yuan Hao
    Warren L. Wu
    23 more author(s)...
    Description

    Lung cancer is the leading cause of cancer related deaths worldwide and immunotherapy has become an important therapeutic intervention. Immunotherapy for lung cancer patients often fails with specific mutations like KEAP1. This study examined the impact of KEAP1 mutations on cancer growth and immune surveillance. They generated an orthotopic transplant model of KrasG12D/+; p53-/- lung cancer with cells...

    Subject
    Cancer
    Genomics
    Access Rights
    Free to All
  • NYU Dataset

    Mapping the Landscape of Histomorphological Cancer Phenotypes Using Self-Supervised Learning on Unannotated Pathology Slides

    Authors
    Adalberto Claudio Quiros
    Nicolas Coudray
    Anna H. Yeaton
    Xinyu Yang
    12 more author(s)...
    Description

    Histomorphological Phenotype Learning (HPL) was developed as a self-supervised methodology to discriminatory features in microscopy images to aid in cancer diagnosis and management. The methodology partitions whole slide images (WSIs) into meaningful Histomorphological Phenotype Clusters (HPCs) that can be used to define and quantify morphological phenotypes which recur within and between cases. HPL...

    Subject
    Cancer
    Chronic Disease
    Access Rights
    Free to All
    Author Approval Required