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NYU Dataset
DIAPH1 Mediates Progression of Atherosclerosis and Regulates Hepatic Lipid Metabolism in Mice
- Authors
- Laura SenatusLander Egana-GorronoRaquel Lopez-DiezSonia Bergaya17 more author(s)...
- Description
Previous study indicated that the receptor for advanced glycation end products (RAGE) in the progression and regression of atherosclerosis. Therefore, this study examined if Diaphanous 1 (DIAPH1) binds to the RAGE cytoplasmic domain and contributes to progression of atherosclerosis. They intercrossed atherosclerosis prone Ldlr−/− mice with mice devoid of Diaph1 and fed them Western diet for 16 weeks....
- Subject
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Genomics
- Access Rights
- Free to All
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NYU Dataset
FITM2 Deficiency Promotes Hepatic ER Stress in Vitro and in Vivo
- Authors
- Haizhen WangCyrus NikainKonstantinos I. FortounasJaume Amengual14 more author(s)...
- Description
This study examined the role of hepatic FITM2, an endoplasmic reticulum (ER) protein, in the partitioning of newly-synthesized triglyceride between the ER, lipid droplets, and nascent very low density lipoprotein (VLDL) particles in vitro and in vivo. The experiments were conducted using a rat hepatic cell line (McA cells) and mice. Effects of FITM2 deficiency on VLDL assembly and secretion in vitro...
- Subject
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Proteomics
- Access Rights
- Application RequiredAuthor Approval Required
