NYU Data Catalog

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  • NYU Dataset

    Immune Responses Observed Before and After BNT162b2 mRNA Vaccine Administration in Individuals with and without History of SARS-CoV-2 Infection

    Authors
    Marie I. Samanovic
    Amber R. Cornelius
    Sophie L. Gray-Gaillard
    Joseph Richard Allen
    7 more author(s)...
    Description

    To study and compare longitudinal immune responses to two-dose BNT162b2 mRNA vaccinations, investigators recruited 15 adults with a history of laboratory-confirmed COVID-19 and 21 adults who did not have COVID-19. Participants' ages ranged from 21 to 65 years old. Peripheral immune responses were assessed via blood samples drawn before and after each vaccine dose. A total of five samples were collected...

    Subject
    COVID-19
    Infectious Disease
    Timeframe
    2021
    Access Rights
    Free to All
  • NYU Dataset

    mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection

    Authors
    Ellie Ivanova
    Jasmine Shwetar
    Joseph C. Devlin
    Terkild B. Buus
    17 more author(s)...
    Description

    To investigate immune responses to SARS-CoV-2 antigens under various inflammatory conditions, researchers collected blood samples from five adult patients seen at NYU Langone Health with lab-confirmed cases of acute COVID-19 and from nine healthy adults (seven who had received the BNT162b2 mRNA vaccine and two with no prior exposure to SARS-CoV-2). Samples were obtained at multiple time points. Patients...

    Subject
    COVID-19
    Genomics
    Infectious Disease
    Access Rights
    Free to All
  • NYU Dataset

    Targeting of Intracellular Oncoproteins with Peptide-Centric Chimeric Antigen Receptors

    Authors
    Mark Yarmarkovich
    Quinlen F. Marshall
    John M. Warrington
    Rasika Premaratne
    24 more author(s)...
    Description

    This study demonstrated that the neuroblastoma immunopeptidome is enriched with peptides derived from proteins essential for tumorigenesis. They targeted the unmutated peptide QYNPIRTTF discovered on HLA-A*24:02, which is derived from the neuroblastoma-dependency gene and master transcriptional regulator PHOX2B. To target QYNPIRTTF, they developed peptide-centric chimeric antigen receptors (PC-CARs)...

    Subject
    Cancer
    Proteomics
    Access Rights
    Free to All